Annals of African Medicine

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 18  |  Issue : 4  |  Page : 200--205

Early signs of microvascular complications in pediatric patients with short duration of type 1 diabetes mellitus seen in southeast Nigeria


Chinwe Flora Ogugua1, Ugo Nnenna Chikani2, Maryann Ugochi Ibekwe1, Thomas Ngwieri3, Holley Allen4 
1 Department of Paediatrics, Federal Teaching Hospital, Abakaliki, Ebonyi State, Nigeria
2 Department of Paediatrics, University of Nigeria, Ituku Ozalla Campus, Enugu, Nigeria
3 Department of Paediatrics, Gertrude's Children's Hospital, Nairobi, Kenya
4 Department of Paediatrics, Baystate Children's Hospital/UMass Medical School, Springfield, MA, USA

Correspondence Address:
Dr. Ugo Nnenna Chikani
University of Nigeria Teaching Hospital, P.M.B 102, Ituku Ozalla, Enugu
Nigeria

Background: Clinically evident microvascular complications are rarely seen among children and adolescents with type 1 diabetes mellitus (T1DM), although early signs develop during childhood and accelerate during puberty. Aim: The aim of this study was to determine the prevalence of early signs of microvascular complications in children and adolescents aged 9–19 years with a short duration of T1DM by screening for retinopathy and nephropathy. Methods: A cross-sectional study and participants were consecutively enrolled from the Endocrinology Clinic at Federal Teaching Hospital, Abakaliki. Physical examination and mydriatic ophthalmoscopy were conducted. Three early morning spot urine specimens for albumin/creatinine ratio were estimated 3 months apart. Serum creatinine levels were estimated, and the glomerular filtration rate was calculated. Glycosylated hemoglobin (HbA1c) was determined. Results: Twenty-four individuals participated, 15 (62.5%) were male and the mean age at diagnosis was 12.4 ± 2.3 years. The mean duration of diabetes was 23.8 ± 20.6 months. The mean HbA1c was 11.4%. Retinopathy was seen in 16.7%, whereas 33.3% had microalbuminuria. Blood pressure range was within the 50th–90th percentile for all the participants. Conclusion: The study outcome demonstrated a high prevalence of early signs of microvascular complications such as retinopathy and nephropathy among youths with short duration of T1DM. Poor glycemic control, if not halted, is associated with early signs of microvascular complications which may become clinically evident; contrary to the belief that they are rare in childhood.


How to cite this article:
Ogugua CF, Chikani UN, Ibekwe MU, Ngwieri T, Allen H. Early signs of microvascular complications in pediatric patients with short duration of type 1 diabetes mellitus seen in southeast Nigeria.Ann Afr Med 2019;18:200-205


How to cite this URL:
Ogugua CF, Chikani UN, Ibekwe MU, Ngwieri T, Allen H. Early signs of microvascular complications in pediatric patients with short duration of type 1 diabetes mellitus seen in southeast Nigeria. Ann Afr Med [serial online] 2019 [cited 2020 Oct 24 ];18:200-205
Available from: https://www.annalsafrmed.org/article.asp?issn=1596-3519;year=2019;volume=18;issue=4;spage=200;epage=205;aulast=Ogugua;type=0