Year : 2016 | Volume
: 15 | Issue : 1 | Page : 14--19
Relationship between serum leptin and insulin resistance among obese Nigerian women
Ifeyinwa Osegbe1, Henry Okpara2, Elaine Azinge3
1 Department of Chemical Pathology, University of Nigeria Teaching Hospital, Enugu, Nigeria
2 Department of Chemical Pathology, University of Calabar Teaching Hospital, Calabar, Nigeria
3 Department of Clinical Pathology, Lagos University Teaching Hospital, Idi-araba, Lagos, Nigeria
Background: Leptin is a hormone produced directly from adipocytes and has been associated with type 2 diabetes mellitus (T2DM) which is characterized by insulin resistance (IR). Due to the increasing prevalence of obesity in sub-Saharan Africa, serum leptin can be explored as a predictive risk factor for T2DM. Therefore, the aim of this study was to determine the relationship between serum leptin and IR among obese women.
Methods: This was a cross-sectional study of obese, adult Nigerian females. Participants with body mass index (BMI) ≥30 kg/m2 and nondiabetic were recruited as subjects. Fasting serum leptin, insulin, and plasma glucose were determined. IR was calculated using the formula: Homeostatic model assessment-IR (HOMA-IR) = (glucose × insulin)/22.5. Statistical analyses were performed using SPSS and P < 0.05 was considered to be significant.
Results: Eighty obese females with mean ± standard deviation BMI 39.1 ± 7.2 kg/m2 and serum leptin level 48.4 ± 24.4 ng/ml participated in study. Prevalence of hyperleptinemia was 92.5% (confidence interval: 87.3–97.7%). The relationship between leptin and HOMA-IR among the subjects was: BMI 30–34.9 kg/m2: n = 27, r = 0.18, P = 0.42; BMI 35–39.9 kg/m2: n = 24, r = 0.36, P = 0.11; BMI ≥ 40 kg/m2: n = 29, r = 0.52, P = 0.004*; and after controlling for BMI (n = 29, r = 0.46, P = 0.014*). Multiple linear regression showed that leptin did not predict for IR (P = 0.837).
Conclusion: Serum leptin levels were positively correlated with IR, which was significant among the Class III (morbid) obesity class. However, leptin was not a predictive factor for IR in obese Nigerian women.
Department of Chemical Pathology, University of Nigeria Teaching Hospital, Ituku.Ozalla, Enugu
|How to cite this article:|
Osegbe I, Okpara H, Azinge E. Relationship between serum leptin and insulin resistance among obese Nigerian women.Ann Afr Med 2016;15:14-19
|How to cite this URL:|
Osegbe I, Okpara H, Azinge E. Relationship between serum leptin and insulin resistance among obese Nigerian women. Ann Afr Med [serial online] 2016 [cited 2023 Feb 2 ];15:14-19
Available from: https://www.annalsafrmed.org/article.asp?issn=1596-3519;year=2016;volume=15;issue=1;spage=14;epage=19;aulast=Osegbe;type=0