Annals of African Medicine

LETTER TO THE EDITOR
Year
: 2013  |  Volume : 12  |  Issue : 3  |  Page : 191--192

Response to comments "obesity paradox" or methodologic error


Adebayo Oyedeji 
 Department of Medicine, Ladoke Akintola University Teaching Hospital, Osogbo, Nigeria

Correspondence Address:
Adebayo Oyedeji
Department of Medicine, Ladoke Akintola University Teaching Hospital, Osogbo
Nigeria




How to cite this article:
Oyedeji A. Response to comments "obesity paradox" or methodologic error.Ann Afr Med 2013;12:191-192


How to cite this URL:
Oyedeji A. Response to comments "obesity paradox" or methodologic error. Ann Afr Med [serial online] 2013 [cited 2021 Jan 22 ];12:191-192
Available from: https://www.annalsafrmed.org/text.asp?2013/12/3/191/117634


Full Text

We appreciate the comments raised and our response is as follows; the "Obesity paradox" has not only been defined with respect to patients with myocardial infarction, but also in patients with heart failure (HF) resulting from multiple etiologies. [1],[2] In fact, in the Kenchaiah et al., study group, while ischemic heart disease was the predominant cause of HF in lower body mass index (BMI) categories, hypertension was the primary factor attributable to HF in higher BMI categories. [3]

In the study by Tanalp et al., [4] they examined 96 obese subjects, and 50 normoweight subjects, without any history of a systemic disease and/or medication use. This contrasts the HF population on medications in our study [5] and so it might be difficult to directly compare the results of both studies. However, from the study by Tanalp et al., we acknowledge that there is a need to attempt to verify the results in our own study population by novel advanced echocardiographic methods.

References

1Horwich TB, Fonarow GC, Hamilton MA, MacLellan WR, Woo MA, Tillisch JH. The relationship between obesity and mortality in patients with heart failure. J Am Coll Cardiol 2001;38:789-95.
2Curtis JP, Selter JG, Wang Y, Rathore SS, Jovin IS, Jadbabaie F, et al. The obesity paradox: Body mass index and outcomes in patients with heart failure. Arch Intern Med 2005;165:55-61.
3Kenchaiah S, Pocock SJ, Wang D, Finn PV, Zornoff LA, Skali H, et al. CHARM Investigators. Body mass index and prognosis in patients with chronic heart failure: Insights from the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) program. Circulation 2007;116:627-36.
4Tanalp AC, Bitigen A, Cevik C, Demir D, Ozveren O, Tigen K, et al. The role of tissue Doppler study in the assessment of left ventricular dysfunction in obesity. Acta Cardiol 2008;63:541-6.
5Oyedeji AT, Balogun MO, Akintomide AO, Sunmonu TA, Adebayo RA, Ajayi OE. The "Obesity paradox" in Nigerians with heart failure. Ann Afr Med 2012;11:212-6.