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Table of Contents
REVIEW ARTICLE
Year : 2019  |  Volume : 18  |  Issue : 3  |  Page : 121-126  

Inflammation and cancer

Nitin Singh1, Deepak Baby2, Jagadish Prasad Rajguru3, Pankaj B Patil4, Savita S Thakkannavar5, Veena Bhojaraj Pujari6
1 Department of Pedodontics and Preventive Dentistry, Chandra Dental College and Hospital, Safedabad, Barabanki, Uttar Pradesh, India
2 Department of Conservative and Endodontics, P.S.M Dental College and Research Centre, Akkikavu, Thrissur, Kerala, India
3 Department of Oral Pathology and Microbiology, Hi-Tech Dental College and Hospital, Bhubaneswar, Odisha, India
4 Department of Oral and Maxillofacial Surgery, School of Dental Sciences, Krishna Institute of Health Sciences Deemed to be University, Karad, Maharashtra, India
5 Department of Oral Pathology and Microbiology, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur, Maharashtra, India
6 Department of Oral Medicine and Radiology, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur, Maharashtra, India

Date of Web Publication14-Aug-2019

Correspondence Address:
Dr. Nitin Singh
Chandra Dental College and Hospital, Safedabad, Barabanki, UP
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aam.aam_56_18

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   Abstract 


Inflammation is often associated with the development and progression of cancer. The cells responsible for cancer-associated inflammation are genetically stable and thus are not subjected to rapid emergence of drug resistance; therefore, the targeting of inflammation represents an attractive strategy both for cancer prevention and for cancer therapy. Tumor-extrinsic inflammation is caused by many factors, including bacterial and viral infections, autoimmune diseases, obesity, tobacco smoking, asbestos exposure, and excessive alcohol consumption, all of which increase cancer risk and stimulate malignant progression. In contrast, cancer-intrinsic or cancer-elicited inflammation can be triggered by cancer-initiating mutations and can contribute to malignant progression through the recruitment and activation of inflammatory cells. Both extrinsic and intrinsic inflammations can result in immunosuppression, thereby providing a preferred background for tumor development. The current review provides a link between inflammation and cancer development.

   Abstract in French 

Résumé
L'inflammation est souvent associée au développement et à la progression du cancer. Les cellules responsables de l'inflammation associée au cancer sont génétiquement stables et ne subissent donc pas l'émergence rapide d'une pharmacorésistance; par conséquent, le ciblage de l'inflammation représente une stratégie attrayante à la fois pour la prévention du cancer et pour le traitement du cancer. L'inflammation tumorale extrinsèque est causée par de nombreux facteurs, notamment: infections bactériennes et virales, maladies auto-immunes, obésité, tabagisme, exposition à l'amiante et consommation excessive d'alcool, le tout qui augmentent le risque de cancer et stimulent la progression maligne. En revanche, l'inflammation intrinsèque au cancer ou provoquée par le cancer peut être déclenchée par des mutations initiant un cancer et peuvent contribuer à la progression maligne par le recrutement et l'activation de cellules inflammatoires. Tous les deux les inflammations extrinsèques et intrinsèques peuvent entraîner une immunosuppression, fournissant ainsi un fond préféré pour le développement de la tumeur. le l'examen actuel établit un lien entre l'inflammation et le développement du cancer.

Keywords: Cancer, cells, inflammation


How to cite this article:
Singh N, Baby D, Rajguru JP, Patil PB, Thakkannavar SS, Pujari VB. Inflammation and cancer. Ann Afr Med 2019;18:121-6

How to cite this URL:
Singh N, Baby D, Rajguru JP, Patil PB, Thakkannavar SS, Pujari VB. Inflammation and cancer. Ann Afr Med [serial online] 2019 [cited 2023 Sep 29];18:121-6. Available from: https://www.annalsafrmed.org/text.asp?2019/18/3/121/264320




   Introduction Top


The presence of leukocytes within tumors, observed in the 19th century by Rudolf Virchow, provided the first indication of a possible link between inflammation and cancer. Yet, it is only during the past decade that clear evidence has been obtained that inflammation plays a critical role in tumorigenesis.[1]

However, when inflammation becomes chronic or lasts too long, it can prove harmful and may lead to disease. The role of pro-inflammatory cytokines, chemokines, adhesion molecules, and inflammatory enzymes has been linked with chronic inflammation [Figure 1].[2]
Figure 1: Different faces of inflammation and its role in tumorigenesis

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Chronic inflammation has been found to mediate a wide variety of diseases, including cardiovascular diseases, cancer, diabetes, arthritis, Alzheimer's disease, pulmonary diseases, and autoimmune diseases.[3]

The current review, however, will be restricted to the role of chronic inflammation in cancer. Chronic inflammation has been linked to various steps involved in tumorgenesis, including cellular transformation, promotion, survival, proliferation, invasion, angiogenesis, and metastasis.[4]

Only a minority of all cancers are caused by germline mutations, whereas the vast majority (90%) are linked to somatic mutations and environmental factors. Many environmental causes of cancer and risk factors are associated with some form of chronic inflammation. Up to 20% of cancers are linked to chronic infections, 30% can be attributed to tobacco smoking and inhaled pollutants (such as silica and asbestos), and 35% can be attributed to dietary factors (20% of cancer burden is linked to obesity).[5]

Recent efforts have shed new light on molecular and cellular circuits linking inflammation and cancer. Two pathways have been schematically identified: in the intrinsic pathway, genetic events causing neoplasia initiate the expression of inflammation-related programs that guide the construction of an inflammatory microenvironment, and in the extrinsic pathway, inflammatory conditions facilitate cancer development.[6]

The triggers of chronic inflammation that increase cancer risk or progression include infections (e.g., Helicobacter pylori for gastric cancer and mucosal lymphoma; papillomavirus and hepatitis viruses for cervical and liver carcinomas, respectively), autoimmune diseases (e.g., inflammatory bowel disease for colon cancer), and inflammatory conditions of uncertain origin (e.g., prostatitis for prostate cancer). Cancer-related inflammation, the seventh hallmark of cancer, links to genetic instability.[7]

It was in 1863 that Rudolf Virchow noted leukocytes in neoplastic tissues and made a connection between inflammation and cancer. He suggested that the “lymphoreticular infiltrate” reflected the origin of cancer at sites of chronic inflammation. Over the past 10 years, our understanding of the inflammatory microenvironment of malignant tissues has supported Virchow's hypothesis, and the links between cancer and inflammation are starting to have implications for prevention and treatment.[8]


   Inflammation and Causes Top


Inflammation is the body's response to tissue damage, caused by physical injury, ischemic injury (caused by an insufficient supply of blood to an organ), infection, exposure to toxins, or other types of trauma. The body's inflammatory response causes cellular changes and immune responses that result in repair of the damaged tissue and cellular proliferation (growth) at the site of the injured tissue. Inflammation can become chronic if the cause of the inflammation persists or certain control mechanisms in charge of shutting down the process fail. When these inflammatory responses become chronic, cell mutation and proliferation can result, often creating an environment that is conducive to the development of cancer. The so-called “perfect storm” is an extreme challenge that cancer patients face. This is true for the onset of cancer but also even more important for the advancement of the disease. Various signaling pathways are key contributors in creating epigenetic changes on the outside of the cell, switching on these internal mutations. Therefore, treating the inflammatory causes is always important.

Chronic inflammation has been linked to various steps involved in tumorigenesis, including cellular transformation, promotion, survival, proliferation, invasion, angiogenesis, and metastasis.


   Cancer Development: An Overview Top


Cancer defines malignant neoplasms characterized by metastatic growth. It may occur in almost every organ and tissue relating to a variety of etiologic factors, such as genomic instability and environmental stress.[9]

However, cancer development is still accepted as a multistep process, during which genetic alterations confer specific types of growth advantages; therefore, it drives the progressive transformation from normal cells to malignant cancer cells. Malignant growth is characterized by several key changes: self-sufficiency of growth signals, insensitivity to antigrowth signals, escaping from apoptosis, unregulated proliferation potential, enhanced angiogenesis, and metastasis. Each of these shifts is complicated and accomplished by combined efforts of various signaling processes. In later discussion, we will find that inflammation may contribute to the formation of these cancer phenotypes.[10]


   Mechanisms for the Association between Inflammation and Cancer Top


Chronic inflammation is characterized by sustained tissue damage, damage-induced cellular proliferation, and tissue repair. Cell proliferation in this context is usually correlated with “metaplasia,” a reversible change in cell type. “Dysplasia,” a disorder of cellular proliferation leading to atypical cell production, follows and is regarded as the previous event of carcinoma because it was usually found adjacent to the site of neoplasm.[11]


   Mutagenic Potential of Inflammation Top


The chronic inflammatory microenvironment is predominated by macrophages. Those macrophages, together with other leukocytes, generate high levels of reactive oxygen and nitrogen species to fight infection.[12] However, in a setting of continuous tissue damage and cellular proliferation, the persistence of these infection-fighting agents is deleterious. They may produce mutagenic agents, such as peroxynitrite, which react with DNA and cause mutations in proliferating epithelial and stroma cells. Macrophages and T-lymphocytes may release tumor necrosis factor-alpha (TNF-α) and macrophage migration inhibitory factor to exacerbate DNA damage.[13]

Migration inhibitory factor impairs p53-dependent protective responses, thus causing the accumulation of oncogenic mutations. Migration inhibitory factor also contributes to tumorigenesis by interfering Rb-E2F pathway.


   Helicobacter Pyloriand Cancer Risk Top


The bacterium H. pylori is known to colonize the human stomach and induce chronic atrophic gastritis, intestinal metaplasia, and gastric cancer. H. pylori infection is a major risk factor for gastric cancer development, which is one of the most challenging malignant diseases worldwide with limited treatments.[14]

The multistep pathogenesis of gastric cancer is the best highlighted by Correa sequence that explains the progressive pathway to gastric cancer characterized by distinct histological changes. This model predicts that infection with H. pylori triggers an inflammatory response resulting in chronic, and then, atrophic, gastritis. This is followed by intestinal metaplasia which can be further classified into complete and incomplete subtypes. At this point, some patients will then proceed to gastric cancer via the intermediate stage of dysplasia [Figure 2].[15]
Figure 2: Correa sequence

Click here to view


The improvement or elimination of atrophy and intestinal metaplasia with H. pylori eradication could potentially inhibit gastric carcinogenesis. It is noteworthy to mention that gastric cancer can still develop even after successful eradication therapy. H. pylori eradication does not result in the regression of all precancerous lesions, which may depend on the degree and extent of preneoplastic changes at the time of eradication.[14]


   Inflammatory Cells in Tumor Microenvironment Top


The inflammatory microenvironment of tumors is characterized by the presence of host leukocytes both in the supporting stroma and in tumor areas.[16] Tumor-infiltrating lymphocytes may contribute to cancer growth and spread and to the immunosuppression associated with malignant disease.

Macrophages

Tumor-associated macrophages (TAM) are a major component of the infiltrate of most, if not all tumors. TAM derives from circulating monocytic precursors and is directed into the tumor by chemoattractant cytokines called chemokines. Many tumor cells also produce cytokines called colony-stimulating factors that prolong the survival of TAM. When appropriately activated, TAM can kill tumor cells or elicit tissue destructive reactions centered on the vascular endothelium. However, TAM also produces growth and angiogenic factors as well as protease enzymes which degrade the extracellular matrix. Hence, TAM can stimulate tumor cell proliferation, promote angiogenesis, and favor invasion and metastasis.[17]

Dendritic cells

Dendritic cells have a crucial role in both the activation of antigen-specific immunity and the maintenance of tolerance, providing a link between innate and adaptive immunity. Tumor-associated dendritic cells (TADCs) usually have an immature phenotype with defective ability to stimulate T-cells.[18]

This distribution of TADC is clearly different from that of TAM, which is evenly scattered in tumor tissue. The immaturity of TADC may reflect lack of effective maturation signals, prompt migration of mature cells to lymph nodes, or the presence of maturation inhibitors. TADC is likely to be poor inducers of effective responses to tumor antigens.

Lymphocytes

Natural killer cells are rare in the tumor microenvironment. The predominant T-cell population has a “memory” phenotype. The cytokine profile of these tumor-infiltrating T-cells has not been studied systematically, but in some tumors (e.g. Kaposi's sarcoma, Hodgkin's disease, bronchial carcinoma, and cervical carcinoma), they produce mainly interleukins (ILs) 4 and 5 and not interferon. IL-4 and 5 are cytokines associated with the T-helper type 2 (Th2) cells, whereas interferon is associated with Th1 responses.[19]


   Key Molecular Players in Linking Inflammation to Cancer Top


To address the details of transition from inflammation to cancers and the further development of inflammation-associated cancers, it is necessary to investigate specific roles of key regulatory molecules involved in this process.

Pro-inflammatory cytokines

The cytokine network of several common tumors is rich in inflammatory cytokines, growth factors, and chemokines but generally lacks cytokines involved in specific and sustained immune responses.[20]

There is now evidence that inflammatory cytokines and chemokines, which can be produced by the tumor cells and/or tumor-associated leukocytes and platelets, may contribute directly to malignant progression. Many cytokines and chemokines are inducible by hypoxia, which is a major physiological difference between tumor and normal tissue. Examples are TNF, IL-1 and 6, and chemokines.

The immune response to tumors is constituted by cytokines produced by tumor cells as well as host stromal cells. Tumor-derived cytokines, such as Fas ligand, vascular endothelial growth factor (VEGF), and transforming growth factor-h, may facilitate the suppression of immune response to tumors. Moreover, inflammatory cytokines have also been reported to facilitate the spectrum of tumor development.[21]

Tumor necrosis factor

TNF is a multifunctional cytokine that plays important roles in diverse cellular events such as cell survival, proliferation, differentiation, and death. As a pro-inflammatory cytokine, TNF is secreted by inflammatory cells, which may be involved in inflammation-associated carcinogenesis. TNF exerts its biological functions through activating distinct signaling pathways such as nuclear factor-κB (NF-κB) and c-Jun N-terminal kinase (JNK). NF-κB is a major cell survival signal that is antiapoptotic while sustained JNK activation contributes to cell death. The crosstalk between the NF-κB and JNK is involved in determining cellular outcomes in response to TNF. TNF is a double-edged sword that could be either pro- or antitumorigenic. On one hand, TNF could be an endogenous tumor promoter because TNF stimulates cancer cells' growth, proliferation, invasion and metastasis, and tumor angiogenesis. On the other hand, TNF could be a cancer killer. The property of TNF in inducing cancer cell death renders it a potential cancer therapeutic.[22]

TNF can be detected in malignant and/or stromal cells in human ovarian, breast, prostate, bladder, and colorectal cancer, lymphomas, and leukemias, often in association with ILs-1 and 6 and macrophage colony-stimulating factor.[23]

Interleukins 1 and 6 in cancer regulation

IL-6 is a pleiotropic cytokine that plays important roles in immune response, inflammation, and hematopoiesis. It is produced by a variety of normal cells including monocytes and macrophages but is also expressed by multiple tumor tissue types, such as breast, prostate, colorectal, and ovarian cancer. IL-6 may also play an important role in various aspects of tumor behavior, including apoptosis, tumor growth cell proliferation, migration and invasion, angiogenesis, and metastasis.[24]

IL-10, initially termed “cytokine synthesis inhibitor” or “cytokine inhibitory factor” due to its inhibitory action on cytokine production by T helper cells, is produced by almost all leukocytes, as well as numerous human tumor cells including breast, kidney, colon, pancreas, malignant melanomas, and neuroblastomas. IL-10 is essential to suppress tumor-promoting inflammation mediators, thereby facilitating tumor growth and metastasis. Specifically, TAMs produce IL-10 and are also associated with in-tumor immunosuppression, thereby providing a suitable microenvironment for cancer growth.[25]

In mouse models of metastasis, treatment with an IL-1 receptor antagonist (which inhibits the action of IL-1) significantly decreased tumor development, suggesting that local production of this cytokine aids the development of metastasis. Moreover, mice deficient in IL-1 were resistant to the development of experimental metastasis.[26]

Chemokines

Inflammatory cytokines are major inducers of a family of chemoattractant cytokines called chemokines that play a central role in leukocyte recruitment to sites of inflammation. Most tumors produce chemokines of the two major groups α (or CXC) and β.

Typically, CXC chemokines are active on neutrophils and lymphocytes, whereas CC chemokines act on several leukocyte subsets including monocytes, eosinophils, dendritic cells, lymphocytes, and natural killer cells but not neutrophils.[27]

Human and murine tumors also frequently secrete CXC chemokines such as IL-8. These chemokines are potent neutrophil attractants, yet neutrophils are rare in tumors. However, both IL-8 and a related chemokine called “gro” induce proliferation and migration of melanoma cell.


   Implications for Prevention and Treatment Top


Tumor necrosis factor blockade

TNF antagonists (etanercept [Enbrel] and infliximab [Remicade]) have been licensed for a clinical trial in the treatment of rheumatoid arthritis and Crohn's disease, with over 70,000 patients now treated. Thalidomide inhibits the processing of mRNA for TNF and VEGF, and continuous low-dose thalidomide has shown activity in patients with advanced myeloma. The role of etanercept in ameliorating the adverse effects of other cancer therapies is also being evaluated. There are also ongoing and planned clinical trials with infliximab. As with other “biological” approaches to cancer treatment, anti-TNF therapy may be optimal in an adjuvant setting with minimal disease.[28]

Chemokine antagonism

Chemokine receptors belong to a family of receptors (transmembrane G-protein-coupled receptors) which is already a target of pharmacological interest. Tumors driven by chemokines and those where chemokines are implicated in metastasis (e.g. seeding to lymph nodes) may be an appropriate target for chemokine antagonists now under development.[29]

IL-6 is a major growth factor for myeloma cells. In advanced disease, there is an excess of IL-6 production, and raised serum concentrations are associated with plasmablastic proliferative activity and short survival.

Nonsteroidal anti-inflammatory agents

Nonsteroidal anti-inflammatory drugs (NSAIDs) are nonselective or selective COX-1/2 inhibitors, which are wildly prescribed for pain killing, fever reduction, and even anti-inflammation.

Patients on NSAIDs are at reduced risk of colon cancer. This may also be true for cancers of the esophagus, stomach, and rectum, and in rodents experimental bladder, breast, and colon cancer. Colon cancer is reduced when NSAIDs are administered concurrently with carcinogens. NSAIDs inhibit cyclooxygenase enzymes and angiogenesis.[30]

The mechanisms involved in the association between NSAIDs and distant metastasis inhibition remain incompletely investigated. One possible explanation is that NSAIDs inhibit COX2. Abnormally high COX2 expression is observed in multicancers. Disordered COX2/PGE pathway is involved in multicancer processes, including carcinogenesis, proliferation, and metastatic spread; in addition, inhibition of COX2/PGE pathway with NSAIDs can restrain cancer cell lines.

Mutual promotion relationship between cancer metastasis and cancer-associated thrombosis is possibly another one of the underlying mechanisms. Abnormally high constitutive level of tissue factor (TF), one key regulator of hemostasis, is expressed by metastatic cancer cells, cancer microparticles, and cancer-associated monocytes and macrophages. TF can promote thrombosis formation by activating the extrinsic pathway of coagulation cascade. Furthermore, inflammation induced by thrombosis could result in endothelial damage that results in the vascular leak, facilitating the escape of cancer cells from blood vessels. Consequently, NSAIDs may disrupt the relationship between cancer metastasis and cancer-associated thrombosis via the suppression of platelet function, which is detrimental for the disseminated cancer cells in the bloodstream.[31]


   Conclusion Top


Overall, this review provides evidence for a strong link between chronic inflammation and cancer. Thus, inflammatory biomarkers as described here can be used to monitor the progression of the disease. These biomarkers can also be exploited to develop new anti-inflammatory drugs to prevent and treat cancer. These drugs can also be used as an adjuvant to the currently available chemotherapy and radiotherapy, which by themselves activate NF-κB and mediate resistance. Numerous anti-inflammatory agents including those identified from natural sources have been shown to exhibit chemopreventive activities.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
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    Figures

  [Figure 1], [Figure 2]


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17 Possible cancer-causing capacity of COVID-19: Is SARS-CoV-2 an oncogenic agent?
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18 The application of antidepressant drugs in cancer treatment
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19 Steatosis in metabolic diseases: A focus on lipolysis and lipophagy
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20 The impact of immunosenescence and inflammaging on the effects of immune checkpoint inhibitors
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21 The therapeutic potential of carnosine: Focus on cellular and molecular mechanisms
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22 Recent trends in STING modulators: structures, mechanisms, and therapeutic potential
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23 Expanding role of CXCR2 and therapeutic potential of CXCR2 antagonists in inflammatory diseases and cancers
Yishi Xie, Wenbin Kuang, Dawei Wang, Kai Yuan, Peng Yang
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24 The effect of 17ß-estradiol plus norethisterone acetate on blood pressure and inflammation markers: A meta-analysis of randomized controlled trials
Hong Liu, Jiang Zhan, Jiao He, Lili Zhong, Jing Yang, Qiaomei Dai, Xianlin Zhang
European Journal of Obstetrics & Gynecology and Reproductive Biology. 2023; 285: 59
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25 The indispensability of macrophage adaptor proteins in chronic inflammatory diseases
Rajat Atre, Rahul Sharma, Gaponenko Vadim, Kundan Solanki, Khandu Wadhonkar, Neha Singh, Pramod Patidar, Rakhi Khabiya, Harshita Samaur, Sreeparna Banerjee, Mirza S. Baig
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26 Identification of the therapeutic effect and molecular mechanism of Coptis chinensis Franch. and Magnolia officinalis var. biloba on chronic gastritis
Jin Song, Xiaolong Xu, Shasha He, Huicun Zhang, Ning Wang, Yunjing Bai, Bo Li, Shengsheng Zhang
Journal of Ethnopharmacology. 2023; : 116864
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27 Extract of Astragali Radix and Solanum nigrum Linne regulates microglia and macrophage polarization and inhibits the growth and infiltration of C6 glioblastoma
Mingxue Shen, Suo Liu, Qin Wei, Xiong Zhang, Shiyu Wen, Runze Qiu, Yingbin Li, Hongwei Fan
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28 Neutrophil elastase: From mechanisms to therapeutic potential
Weilin ZENG, Yingqiu SONG, Runze WANG, Rong HE, Tianlu WANG
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29 Applicability of thermography for cancer diagnosis in small animals
André Gustavo Alves Holanda, Danila Evem Alves Cortez, Genilson Fernandes de Queiroz, Julia Maria Matera
Journal of Thermal Biology. 2023; : 103561
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30 Regulation of inflammation in cancer by dietary eicosanoids
Haixia Yang, Eva Rothenberger, Tong Zhao, Wendong Fan, Abigail Kelly, Ahmed Attaya, Daidi Fan, Dipak Panigrahy, Jianjun Deng
Pharmacology & Therapeutics. 2023; : 108455
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31 Epigenetics in T-cell driven inflammation and cancer
Lea Falkowski, Joerg Buddenkotte, Angeliki Datsi
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32 COVID-19 as a polymorphic inflammatory spectrum of diseases: a review with focus on the brain
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33 Analysis of prognostic factors for vocal fold leukoplakia based on 344 cases at a two-year follow up
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34 Tea Polyphenol Coordinated with Nanoparticles of ZIF-8 and Coated with Polydopamine and PEG for Immuno-Oncotherapy
Nahar Jannatun, Yuqian Zhang, Ben Wu, Qingle Song, Guoli Cao, Wenhe Luo, Feng Yuan, Qi Li, Yanqiao Zeng, Guofang Zhang, Guocheng Wang, Yang Li
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35 T cells in health and disease
Lina Sun, Yanhong Su, Anjun Jiao, Xin Wang, Baojun Zhang
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36 Targeted delivery of paclitaxel drug using polymer-coated magnetic nanoparticles for fibrosarcoma therapy: in vitro and in vivo studies
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37 Platin-C containing nanoparticles: a recipe for the delivery of curcumin–cisplatin combination chemotherapeutics to mitochondria
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38 Study on the effect and mechanisms of piperine against cervical cancer based on network pharmacology and experimental validation
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39 A network pharmacology approach to elucidate the anti-inflammatory effects of ellagic acid
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40 Synthesis of novel thiazoles bearing lupeol derivatives as potent anticancer and anti-inflammatory agents
Kummari Narendar, B. Sambasiva Rao, Satyakrishna Tirunavalli, Surender Singh Jadav, Sai Balaji Andugulapati, Vaikundamoorthy Ramalingam, K. Suresh Babu
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41 Revisiting the Multifaceted Therapeutic Potential of Withaferin A (WA), a Novel Steroidal Lactone, W-ferinAmax (Ashwagandha), from Withania Somnifera (L) Dunal
Pawan Kumar, Samudra P. Banik, Apurva Goel, Sanjoy Chakraborty, Manashi Bagchi, Debasis Bagchi
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42 Decoding Connectivity Map-based drug repurposing for oncotherapy
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43 Kaempferitrin, a major compound from ethanol extract of Chenopodium ambrosioides, exerts antitumour and hepatoprotective effects in the mice model of human liver cancer xenografts
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44 Microgravity and immune cells
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45 Routinary PET/CT imaging for oncological surveillance accompanied by echocardiography may identify early atherosclerotic cardiovascular disease: A case report
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46 An inflammation-associated ferroptosis signature optimizes the diagnosis, prognosis evaluation and immunotherapy options in hepatocellular carcinoma
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47 The evil companion of OSCC: Candida albicans
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48 The p23 co-chaperone is a succinate-activated COX-2 transcription factor in lung adenocarcinoma tumorigenesis
Zhenlong Yu, Yulin Peng, Jian Gao, Meirong Zhou, Lei Shi, Feng Zhao, Chao Wang, Xiangge Tian, Lei Feng, Xiaokui Huo, Baojing Zhang, Min Liu, Deyu Fang, Xiaochi Ma
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49 Analysis of systemic inflammatory and coagulation biomarkers in advanced cervical cancer: Prognostic and predictive significance
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50 Inflammatory microenvironment and immunotherapy in hepatocellular carcinoma
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51 Retrospective study of the combination of TP and PF regimens with or without immune checkpoint inhibitors for the first-line treatment of locally advanced or advanced esophageal squamous cell carcinoma
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52 The prognostic utility of preoperative neutrophil-to-lymphocyte ratio (NLR) in patients with colorectal liver metastasis: a systematic review and meta-analysis
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53 Predictive value of monocyte to high-density lipoprotein cholesterol ratio and tumor markers in colorectal cancer and their relationship with clinicopathological characteristics
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54 Clinical value of combined preoperative–postoperative neutrophil-to-lymphocyte ratio in predicting hepatocellular carcinoma prognosis after radiofrequency ablation
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55 Research Progress of Correlation between Helicobacter pylori Infection and Colorectal Neoplasms
?? ?
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56 The ratio of adaptive to innate immune cells differs between genders and associates with improved prognosis and response to immunotherapy
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57 Dietary inflammatory index and neuropsychiatric disorders
Mahsa Golshani Nasab, Arash Heidari, Mohammadreza Sedighi, Narges Shakerian, Mona Mirbeyk, Amene Saghazadeh, Nima Rezaei
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58 Oxidative Metabolism Genes in Ovarian Neoplasms
Elena V. Proskurnina, Mariya V. Fedorova, Ekaterina A. Savinova, Vladimir I. Voznesenskii, Svetlana V. Kostyuk, Elena A. Sosnova
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59 TIPE2 acts as a tumor suppressor and correlates with tumor microenvironment immunity in epithelial ovarian cancer
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60 TNFR2 promotes pancreatic cancer proliferation, migration, and invasion via the NF-?B signaling pathway
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61 A Novel and Validated Inflammation-Based Prognosis Score (IBPS) Predicts Outcomes in Patients with Diffuse Large B-Cell Lymphoma
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62 Fashionable, but What is Their Real Clinical Usefulness? NLR, LMR, and PLR as a Promising Indicator in Colorectal Cancer Prognosis: A Systematic Review
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Journal of Inflammation Research. 2023; Volume 16: 69
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63 Association of Neutrophil-to-Lymphocyte Ratio with Nutrition in Patients with Various Types of Malignant Tumors: A Multicenter Cross-Sectional Study
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64 Interaction Between Blood Vasculatures and Lymphatic Vasculatures During Inflammation
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65 Roles of cancer stem cells in cancer immune surveillance
Nhat-Chau TRUONG, Nhi-Thao HUYNH, Kmuong-Duy PHAM, Phuc-Van PHAM
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66 The oxidative aging model integrated various risk factors in type 2 diabetes mellitus at system level
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67 Gender- and age-specific associations of childhood maltreatment with peripheral serum inflammatory cytokines in middle school students
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68 Construction of IL-1 signalling pathway correlation model in lung adenocarcinoma and association with immune microenvironment prognosis and immunotherapy: Multi-data validation
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69 Signaling pathways of oxidative stress response: the potential therapeutic targets in gastric cancer
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70 Galectin functions in cancer-associated inflammation and thrombosis
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71 Inflammatory factors and risk of meningiomas: a bidirectional mendelian-randomization study
Zhiyun Zhang, Shengnan Wang, Fei Ren, Laiyu Yang, Haoqun Xie, Lin Pan, Yifan Li, Bingcheng Yu, Yifan Yang, Haoyi Su, Youqi Chen, Chuyi Zhang, Hongyu Chen, Wenzhuo Yang, Nan An, Yang Bai
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72 Research progress on the role and mechanism of miR-671 in bone metabolism and bone-related diseases
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73 Quercetin activates vitamin D receptor and ameliorates breast cancer induced hepatic inflammation and fibrosis
Nirmala G. Sannappa Gowda, Varsha D. Shiragannavar, Lakshana D. Puttahanumantharayappa, Ashwini Tumkur Shivakumar, Siva Dallavalasa, Chaithanya G. Basavaraju, Smitha S. Bhat, Shashanka K. Prasad, Ravishankar M. Vamadevaiah, SubbaRao V. Madhunapantula, Prasanna K. Santhekadur
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74 Prognostic value of neutrophil to lymphocyte ratio in gastric cancer patients receiving immune checkpoint inhibitors: a systematic review and meta-analysis
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75 Prognostic value of inflammatory markers and clinical features for survival in advanced or metastatic esophageal squamous cell carcinoma patients receiving anti-programmed death 1 treatment
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76 In vitro antiproliferative, anti-inflammatory effects and molecular docking studies of natural compounds isolated from Sarcocephalus pobeguinii (Hua ex Pobég)
Emmanuel Mfotie Njoya, Brigitte Ndemangou, Jude Akinyelu, Aristide M. Munvera, Chika. I. Chukwuma, Pierre Mkounga, Samson S. Mashele, Tshepiso J. Makhafola, Lyndy J. McGaw
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77 Immune cell status, cardiorespiratory fitness and body composition among breast cancer survivors and healthy women: a cross sectional study
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78 Biomechanical, Healing and Therapeutic Effects of Stretching: A Comprehensive Review
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79 Exploring the Heart–Mind Connection: Unraveling the Shared Pathways between Depression and Cardiovascular Diseases
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80 The Significance of CXCL1 and CXCR1 as Potential Biomarkers of Colorectal Cancer
Marta Lukaszewicz-Zajac, Monika Zajkowska, Sara Paczek, Agnieszka Kulczynska-Przybik, Kamil Safiejko, Marcin Juchimiuk, Leszek Kozlowski, Barbara Mroczko
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81 Discovering the Clinical and Prognostic Role of Pan-Immune-Inflammation Values on Oral Cavity Squamous Cell Carcinoma
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82 Metabolic Health, Mitochondrial Fitness, Physical Activity, and Cancer
Vicente Javier Clemente-Suárez, Alexandra Martín-Rodríguez, Laura Redondo-Flórez, Pablo Ruisoto, Eduardo Navarro-Jiménez, Domingo Jesús Ramos-Campo, José Francisco Tornero-Aguilera
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83 Potential Pathophysiological Pathways in the Complex Relationships between OSA and Cancer
Manuel Sánchez-de-la-Torre, Carolina Cubillos, Olivia J. Veatch, Francisco Garcia-Rio, David Gozal, Miguel Angel Martinez-Garcia
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84 Inflammatory Networks in Renal Cell Carcinoma
Linus Kruk, Medina Mamtimin, Attila Braun, Hans-Joachim Anders, Joachim Andrassy, Thomas Gudermann, Elmina Mammadova-Bach
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85 Protective Effects of Influenza Vaccine against Colorectal Cancer in Populations with Chronic Kidney Disease: A Nationwide Population-Based Cohort Study
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86 Natural Products for the Prevention, Treatment and Progression of Breast Cancer
Fabiano Svolacchia, Sergio Brongo, Alessia Catalano, Agostino Ceccarini, Lorenzo Svolacchia, Alessandro Santarsiere, Carmen Scieuzo, Rosanna Salvia, Francesca Finelli, Luigi Milella, Carmela Saturnino, Maria Stefania Sinicropi, Tommaso Fabrizio, Federica Giuzio
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87 Effectiveness of Therapeutic Education in Patients with Cancer Pain: Systematic Review and Meta-Analysis
Ana María González-Martín, Iván Aguilera-García, Yolanda Castellote-Caballero, Yulieth Rivas-Campo, Antonio Bernal-Suárez, Agustín Aibar-Almazán
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88 Nanotechnology-Based Drug Delivery Approaches of Mangiferin: Promises, Reality and Challenges in Cancer Chemotherapy
Muhammad Sarfraz, Abida Khan, Gaber El-Saber Batiha, Muhammad Furqan Akhtar, Ammara Saleem, Basiru Olaitan Ajiboye, Mehnaz Kamal, Abuzer Ali, Nawaf M. Alotaibi, Shams Aaghaz, Muhammad Irfan Siddique, Mohd Imran
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89 The Interplay between Dysregulated Metabolism and Epigenetics in Cancer
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90 The Role of Inflammation in CKD
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91 Molecular Evaluation of the Impact of Polymorphic Variants in Apoptotic (Bcl-2/Bax) and Proinflammatory Cytokine (TNF-a/IL-8) Genes on the Susceptibility and Progression of Myeloproliferative Neoplasms: A Case-Control Biomarker Study
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92 Pathomorphological Manifestations and the Course of the Cervical Cancer Disease Determined by Variations in the TLR4 Gene
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93 Pathways Affected by Falcarinol-Type Polyacetylenes and Implications for Their Anti-Inflammatory Function and Potential in Cancer Chemoprevention
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94 Therapeutic Applications and Effects of Lupinus angustifolius (Blue Lupin) and Its Components: A Systematic Review and Meta-Analysis
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95 Donkey Oil-Based Ketogenic Diet Prevents Tumor Progression by Regulating Intratumor Inflammation, Metastasis and Angiogenesis in CT26 Tumor-Bearing Mice
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96 Crosstalk of Inflammatory Cytokines within the Breast Tumor Microenvironment
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97 Role of Plant-Derived Compounds in the Molecular Pathways Related to Inflammation
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98 Role of Antioxidant Vitamins and Other Micronutrients on Regulations of Specific Genes and Signaling Pathways in the Prevention and Treatment of Cancer
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99 Effects of Obesity and Calorie Restriction on Cancer Development
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100 The Role of Specialized Pro-Resolving Lipid Mediators in Inflammation-Induced Carcinogenesis
Wheeler Torres, José Luis Pérez, María P. Díaz, Luis D’Marco, Ana Checa-Ros, Rubén Carrasquero, Lissé Angarita, Yosselin Gómez, Maricarmen Chacín, Paola Ramírez, Nelson Villasmil, Samuel Durán-Agüero, Clímaco Cano, Valmore Bermúdez
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101 S100A8 and S100A9 in Hematologic Malignancies: From Development to Therapy
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102 Construction and Verification of the Molecular Subtype and a Novel Prognostic Signature Based on Inflammatory Response-Related Genes in Uveal Melanoma
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103 Lithium: A Promising Anticancer Agent
Edgar Yebrán Villegas-Vázquez, Laura Itzel Quintas-Granados, Hernán Cortés, Manuel González-Del Carmen, Gerardo Leyva-Gómez, Miguel Rodríguez-Morales, Lilia Patricia Bustamante-Montes, Daniela Silva-Adaya, Carlos Pérez-Plasencia, Nadia Jacobo-Herrera, Octavio Daniel Reyes-Hernández, Gabriela Figueroa-González
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104 The Anti-Cancer Effect of Cinnamon Aqueous Extract: A Focus on Hematological Malignancies
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105 Diversity, Biosynthesis and Bioactivity of Aeruginosins, a Family of Cyanobacteria-Derived Nonribosomal Linear Tetrapeptides
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Marine Drugs. 2023; 21(4): 217
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106 Triple Therapy with Metformin, Ketogenic Diet, and Metronomic Cyclophosphamide Reduced Tumor Growth in MYCN-Amplified Neuroblastoma Xenografts
Luca Catalano, Sepideh Aminzadeh-Gohari, Daniela D. Weber, Rodolphe Poupardin, Victoria E. Stefan, William J. Smiles, Julia Tevini, René G. Feichtinger, Sophia Derdak, Martin Bilban, Stefan Bareswill, Markus M. Heimesaat, Barbara Kofler
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107 Screening out Biomarkers of Tetrastigma hemsleyanum for Anti-Cancer and Anti-Inflammatory Based on Spectrum-Effect Relationship Coupled with UPLC-Q-TOF-MS
Jie Xia, Xiuyue Li, Min Lin, Jiani Yu, Zhongda Zeng, Fei Ye, Guanjun Hu, Qiang Miu, Qiuling He, Xiaodan Zhang, Zongsuo Liang
Molecules. 2023; 28(7): 3021
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108 Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings
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Molecules. 2023; 28(9): 3669
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109 Chronic Inflammation’s Transformation to Cancer: A Nanotherapeutic Paradigm
Sayed Sartaj Sohrab, Riya Raj, Amka Nagar, Susan Hawthorne, Ana Cláudia Paiva-Santos, Mohammad Amjad Kamal, Mai M. El-Daly, Esam I. Azhar, Ankur Sharma
Molecules. 2023; 28(11): 4413
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110 Mesosphaerum suaveolens Essential Oil Attenuates Inflammatory Response and Oxidative Stress in LPS-Stimulated RAW 264.7 Macrophages by Regulating NF-?B Signaling Pathway
Omprakash Mohanta, Asit Ray, Sudipta Jena, Ambika Sahoo, Soumya Swarup Panda, Prabhat Kumar Das, Sanghamitra Nayak, Pratap Chandra Panda
Molecules. 2023; 28(15): 5817
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111 Narrow Leafed Lupin (Lupinus angustifolius L.) ß-Conglutin Seed Proteins as a New Natural Cytotoxic Agents against Breast Cancer Cells
Julia Escudero-Feliu, María García-Costela, Sara Moreno-SanJuan, Jose D. Puentes-Pardo, Sandra Ríos Arrabal, Paula González-Novoa, María Isabel Núñez, Ángel Carazo, Jose C. Jimenez-Lopez, Josefa León
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112 In Vitro Antitumor and Anti-Inflammatory Activities of Allium-Derived Compounds Propyl Propane Thiosulfonate (PTSO) and Propyl Propane Thiosulfinate (PTS)
Enrique Guillamón, Nuria Mut-Salud, María Jesús Rodríguez-Sojo, Antonio Jesús Ruiz-Malagón, Antonio Cuberos-Escobar, Antonio Martínez-Férez, Alba Rodríguez-Nogales, Julio Gálvez, Alberto Baños
Nutrients. 2023; 15(6): 1363
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113 Food Anthocyanins: Malvidin and Its Glycosides as Promising Antioxidant and Anti-Inflammatory Agents with Potential Health Benefits
Anna Merecz-Sadowska, Przemyslaw Sitarek, Tomasz Kowalczyk, Karolina Zajdel, Mariusz Jecek, Pawel Nowak, Radoslaw Zajdel
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114 Piperine Reduces Neoplastic Progression in Cervical Cancer Cells by Downregulating the Cyclooxygenase 2 Pathway
Luana Pereira Cardoso, Stefanie Oliveira de Sousa, Juliana Prado Gusson-Zanetoni, Laura Luciana de Melo Moreira Silva, Barbara Maria Frigieri, Tiago Henrique, Eloiza Helena Tajara, Sonia Maria Oliani, Flávia Cristina Rodrigues-Lisoni
Pharmaceuticals. 2023; 16(1): 103
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115 Targeting Inflammation in Non-Small Cell Lung Cancer through Drug Repurposing
Thiviyadarshini Rajasegaran, Chee Wun How, Anoosha Saud, Azhar Ali, Jonathan Chee Woei Lim
Pharmaceuticals. 2023; 16(3): 451
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116 Hyaluronic Acid-Mediated Phenolic Compound Nanodelivery for Cancer Therapy
Simona Serini, Sonia Trombino, Federica Curcio, Roberta Sole, Roberta Cassano, Gabriella Calviello
Pharmaceutics. 2023; 15(6): 1751
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117 Type 1 and type 2 cytokine-mediated immune orchestration in the tumour microenvironment and their therapeutic potential
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118 Development and validation of a novel nomogram for predicting overall survival in gastric cancer based on inflammatory markers
Pan-Quan Luo, En-Dong Song, Fei Liu, Abigail N Rankine, Li-Xiang Zhang, Zhi-Jian Wei, Wen-Xiu Han, A-Man Xu
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119 Prognostic significance of preoperative lymphocyte to monocyte ratio in patients with signet ring gastric cancer
He-Li Liu, Xiang Feng, Mi-Mi Tang, Hai-Yan Zhou, Huan Peng, Jie Ge, Ting Liu
World Journal of Gastrointestinal Surgery. 2023; 15(8): 1673
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120 Papel del virus del papiloma humano en el desarrollo del cáncer del cuello uterino.
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Investigación Clínica. 2023; 64(2): 233
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121 Dietary fatty acid patterns and risk of oesophageal squamous cell carcinoma
Chanchan Hu, Zheng Lin, Zhiqiang Liu, Xuwei Tang, Jianyu Song, Jianbo Lin, Yuanmei Chen, Zhijian Hu
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122 Potential of [11C](R)-PK11195 PET Imaging for Evaluating Tumor Inflammation: A Murine Mammary Tumor Model
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123 Personal predictive model based on systemic inflammation markers for estimation of postoperative pancreatic fistula following pancreaticoduodenectomy
Zhi-Da Long, Chao Lu, Xi-Gang Xia, Bo Chen, Zhi-Xiang Xing, Lei Bie, Peng Zhou, Zhong-Lin Ma, Rui Wang
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124 Diyet Inflamatuar Indeksi, Inflamasyon ve Beslenme
Asghar AMANPOUR, Furkan ÇELEBI, Isik Gülcan KAHRAMAN, Fatma ÇELIK
Türkiye Saglik Bilimleri ve Arastirmalari Dergisi. 2022; : 59
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125 Virus Association with Gastric Inflammation and Cancer: An Updated Overview
Roshika Tyagi, Catherine Paul, Juni Banerjee, Rajeev Kaul, Shuvomoy Banerjee
Journal of Medical Microbiology and Infectious Diseases. 2022; 10(4): 163
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126 In Vivo and In Vitro Studies of Cigarette Smoke Effects on Innate Responses to Influenza Virus: A Matter of Models?
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Viruses. 2022; 14(8): 1824
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127 In-Depth Metaproteomics Analysis of Oral Microbiome for Lung Cancer
Xiaoteng Jiang, Yan Zhang, Huiyu Wang, Zeyuan Wang, Shen Hu, Chengxi Cao, Hua Xiao
Research. 2022; 2022: 1
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128 Therapeutic activities and biological effects of curcumin, as a natural multi-target compound, on human health: A minireview
Fatemeh Paknia, Niloofar Parchami, Negar Nasry, Hassan Mohabatkar
Journal of Shahrekord University of Medical Sciences. 2022; 24(3): 145
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129 Health Benefits and Pharmacological Aspects of Chrysoeriol
Sara Aboulaghras, Nargis Sahib, Saad Bakrim, Taoufiq Benali, Saoulajan Charfi, Fatima-Ezzahrae Guaouguaou, Nasreddine El Omari, Monica Gallo, Domenico Montesano, Gokhan Zengin, Khalid Taghzouti, Abdelhakim Bouyahya
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130 Anti-Inflammatory Activity and Mechanism of Cryptochlorogenic Acid from Ageratina adenophora
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131 Health Benefits of Apple Juice Consumption: A Review of Interventional Trials on Humans
Bastien Vallée Marcotte, Marie Verheyde, Sonia Pomerleau, Alain Doyen, Charles Couillard
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132 The Employment of Genera Vaccinium, Citrus, Olea, and Cynara Polyphenols for the Reduction of Selected Anti-Cancer Drug Side Effects
Jessica Maiuolo, Vincenzo Musolino, Micaela Gliozzi, Cristina Carresi, Francesca Oppedisano, Saverio Nucera, Federica Scarano, Miriam Scicchitano, Lorenza Guarnieri, Francesca Bosco, Roberta Macrì, Stefano Ruga, Antonio Cardamone, Anna Rita Coppoletta, Sara Ilari, Annachiara Mollace, Carolina Muscoli, Francesco Cognetti, Vincenzo Mollace
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133 Tackling Surgical Morbidity and Mortality through Modifiable Risk Factors in Cancer Patients
Boram Lee, Ho-Seong Han
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134 Vitamin–Microbiota Crosstalk in Intestinal Inflammation and Carcinogenesis
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135 The Exploration of Chemokines Importance in the Pathogenesis and Development of Endometrial Cancer
Jakub Dobroch, Klaudia Bojczuk, Adrian Kolakowski, Marta Baczewska, Pawel Knapp
Molecules. 2022; 27(7): 2041
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136 Crocodile Oil Modulates Inflammation and Immune Responses in LPS-Stimulated RAW 264.7 Macrophages
Metas Ngernjan, Atcharaporn Ontawong, Narissara Lailerd, Kriangsak Mengamphan, Sureeporn Sarapirom, Doungporn Amornlerdpison
Molecules. 2022; 27(12): 3784
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137 Wistin Exerts an Anti-Inflammatory Effect via Nuclear Factor-?B and p38 Signaling Pathways in Lipopolysaccharide-Stimulated RAW264.7 Cells
Jangeun An, Gyoungah Ryu, Seong-Ah Shin, Huiji Kim, Mi-Jeong Ahn, Jun Hyuck Lee, Chang Sup Lee
Molecules. 2022; 27(17): 5719
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138 Personalized Medicine in the Field of Inflammatory Skin Disorders
Mircea Tampa, Monica Neagu, Constantin Caruntu, Simona Roxana Georgescu
Journal of Personalized Medicine. 2022; 12(3): 426
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139 Mitochondrial Sirtuins in Chronic Degenerative Diseases: New Metabolic Targets in Colorectal Cancer
Antonino Colloca, Anna Balestrieri, Camilla Anastasio, Maria Luisa Balestrieri, Nunzia D’Onofrio
International Journal of Molecular Sciences. 2022; 23(6): 3212
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140 Antiphospholipid Antibodies and Lipids in Hematological Malignancies
Sonia Guadalupe Barreno-Rocha, Sandra Guzmán-Silahua, Sinaí-del-Carmen Rodríguez-Dávila, Guadalupe Estela Gavilanez-Chávez, Ernesto Germán Cardona-Muñoz, Carlos Riebeling-Navarro, Benjamín Rubio-Jurado, Arnulfo Hernán Nava-Zavala
International Journal of Molecular Sciences. 2022; 23(8): 4151
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141 Granzymes—Their Role in Colorectal Cancer
Sara Paczek, Marta Lukaszewicz-Zajac, Barbara Mroczko
International Journal of Molecular Sciences. 2022; 23(9): 5277
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142 Emerging Roles of the Iron Chelators in Inflammation
Alessandra Di Paola, Chiara Tortora, Maura Argenziano, Maria Maddalena Marrapodi, Francesca Rossi
International Journal of Molecular Sciences. 2022; 23(14): 7977
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143 The Crucial Roles of Bmi-1 in Cancer: Implications in Pathogenesis, Metastasis, Drug Resistance, and Targeted Therapies
Jie Xu, Lin Li, Pengfei Shi, Hongjuan Cui, Liqun Yang
International Journal of Molecular Sciences. 2022; 23(15): 8231
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144 Mechanisms Underlying Anti-Inflammatory and Anti-Cancer Properties of Stretching—A Review
Malgorzata Król, Patrycja Kupnicka, Mateusz Bosiacki, Dariusz Chlubek
International Journal of Molecular Sciences. 2022; 23(17): 10127
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145 Delving into the Heterogeneity of Different Breast Cancer Subtypes and the Prognostic Models Utilizing scRNA-Seq and Bulk RNA-Seq
Jieyun Xu, Shijie Qin, Yunmeng Yi, Hanyu Gao, Xiaoqi Liu, Fei Ma, Miao Guan
International Journal of Molecular Sciences. 2022; 23(17): 9936
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146 Toll-like Receptor Mediation in SARS-CoV-2: A Therapeutic Approach
Abdul Manan, Rameez Hassan Pirzada, Muhammad Haseeb, Sangdun Choi
International Journal of Molecular Sciences. 2022; 23(18): 10716
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147 Oxidative Stress and DNA Damage Markers in Colorectal Cancer
Delia Acevedo-León, Lidia Monzó-Beltrán, Laura Pérez-Sánchez, Eva Naranjo-Morillo, Segundo Ángel Gómez-Abril, Nuria Estañ-Capell, Celia Bañuls, Guillermo Sáez
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148 Inflammation in Pulmonary Hypertension and Edema Induced by Hypobaric Hypoxia Exposure
Samia El Alam, Eduardo Pena, Diego Aguilera, Patricia Siques, Julio Brito
International Journal of Molecular Sciences. 2022; 23(20): 12656
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149 Alpha-1 Antitrypsin Inhibits Tumorigenesis and Progression of Colitis-Associated Colon Cancer through Suppression of Inflammatory Neutrophil-Activated Serine Proteases and IGFBP-3 Proteolysis
Qing Cai, Minsun Kim, Aki Harada, Michael O. Idowu, Gobalakrishnan Sundaresan, Jamal Zweit, Youngman Oh
International Journal of Molecular Sciences. 2022; 23(22): 13737
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150 The Role of microRNAs in Inflammation
Kaushik Das, L. Vijaya Mohan Rao
International Journal of Molecular Sciences. 2022; 23(24): 15479
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151 The Role of Inflammation in Anal Cancer
Amir Selimagic, Ada Dozic, Azra Husic-Selimovic, Nijaz Tucakovic, Amir Cehajic, Anela Subo, Azra Spahic, Nedim Vanis
Diseases. 2022; 10(2): 27
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152 Growth Hormone-Releasing Hormone Antagonist JV-1-36 Suppresses Reactive Oxygen Species Generation in A549 Lung Cancer Cells
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Endocrines. 2022; 3(4): 813
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153 Nutritional and Exercise Interventions in Cancer-Related Cachexia: An Extensive Narrative Review
Vicente Javier Clemente-Suárez, Laura Redondo-Flórez, Alejandro Rubio-Zarapuz, Ismael Martínez-Guardado, Eduardo Navarro-Jiménez, José Francisco Tornero-Aguilera
International Journal of Environmental Research and Public Health. 2022; 19(8): 4604
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154 Risk of Anorectal Cancer Associated with Benign Anal Inflammatory Diseases: A Retrospective Matched Cohort Study
Wonjeong Chae, Seung Yeon Kang, Sung-In Jang, Yoon Dae Han
International Journal of Environmental Research and Public Health. 2022; 19(12): 7467
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155 Seaweed Derived Lipids Are a Potential Anti-Inflammatory Agent: A Review
Agnieszka Jaworowska, Aliza Murtaza
International Journal of Environmental Research and Public Health. 2022; 20(1): 730
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156 Tumor HPV Status, Level of Regulatory T Cells and Macrophage Infiltration Predict up to 20-Year Non-Disease-Specific Survival in Oropharynx Squamous Cell Carcinoma Patients
Hilde Haave, Borghild Ljokjel, Helene Lybak, Svein E. Moe, Jan E. Berge, Olav K. Vintermyr, Lars Helgeland, Hans J. Aarstad
Biomedicines. 2022; 10(10): 2484
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157 Loss of Chemerin in Rhabdomyosarcoma Cells Polarizes Adjacent Monocytes to an Immunosuppressive Phenotype
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Biomedicines. 2022; 10(10): 2610
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158 Insulin-Degrading Enzyme, an Under-Estimated Potential Target to Treat Cancer?
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Cells. 2022; 11(7): 1228
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159 Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs
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Cells. 2022; 11(8): 1312
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160 Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs
Miguel Ángel Olmedo-Suárez, Ivonne Ramírez-Díaz, Andrea Pérez-González, Alejandro Molina-Herrera, Miguel Ángel Coral-García, Sagrario Lobato, Pouya Sarvari, Guillermo Barreto, Karla Rubio
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161 The Role of ApoE Serum Levels and ApoE Gene Polymorphisms in Patients with Laryngeal Squamous Cell Carcinoma
Rasa Liutkeviciene, Justina Auzelyte, Vykintas Liutkevicius, Alvita Vilkeviciute, Greta Gedvilaite, Paulius Vaiciulis, Virgilijus Uloza
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162 Novel Risk Classification Based on Pyroptosis-Related Genes Defines Immune Microenvironment and Pharmaceutical Landscape for Hepatocellular Carcinoma
Jianye Wang, Ying Wang, Marcella Steffani, Christian Stöß, Donna Ankerst, Helmut Friess, Norbert Hüser, Daniel Hartmann
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163 Gall Bladder Disease and the Risk of Small Bowel Cancer—Results from a Nationwide Swedish Cohort Study
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Cancers. 2022; 14(3): 469
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164 Inflammation, Fibrosis and Cancer: Mechanisms, Therapeutic Options and Challenges
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Cancers. 2022; 14(3): 552
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165 Tumor Infiltration Levels of CD3, Foxp3 (+) Lymphocytes and CD68 Macrophages at Diagnosis Predict 5-Year Disease-Specific Survival in Patients with Oropharynx Squamous Cell Carcinoma
Borghild Ljokjel, Hilde Haave, Stein Lybak, Olav Karsten Vintermyr, Lars Helgeland, Hans Jørgen Aarstad
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166 Immunomodulation by Gut Microbiome on Gastrointestinal Cancers: Focusing on Colorectal Cancer
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167 The Association between the Pan-Immune-Inflammation Value and Cancer Prognosis: A Systematic Review and Meta-Analysis
Deniz Can Guven, Taha Koray Sahin, Enes Erul, Saadettin Kilickap, Thilo Gambichler, Sercan Aksoy
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168 Microbiota and the Immune System—Actors in the Gastric Cancer Story
Marek Majewski, Paulina Mertowska, Sebastian Mertowski, Konrad Smolak, Ewelina Grywalska, Kamil Torres
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169 Lung Adenocarcinoma Cell Sensitivity to Chemotherapies: A Spotlight on Lipid Droplets and SREBF1 Gene
Anna Ricarda Gründing, Marc A. Schneider, Sarah Richtmann, Mark Kriegsmann, Hauke Winter, Beatriz Martinez-Delgado, Sarai Varona, Bin Liu, David S. DeLuca, Julia Held, Sabine Wrenger, Thomas Muley, Michael Meister, Tobias Welte, Sabina Janciauskiene
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170 Nomograms Based on Fibrinogen, Albumin, Neutrophil-Lymphocyte Ratio, and Carbohydrate Antigen 125 for Predicting Endometrial Cancer Prognosis
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171 The Study of the Extracellular Matrix in Chronic Inflammation: A Way to Prevent Cancer Initiation?
Asia Marangio, Andrea Biccari, Edoardo D’Angelo, Francesca Sensi, Gaya Spolverato, Salvatore Pucciarelli, Marco Agostini
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172 Investigational Microbiological Therapy for Glioma
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173 Preoperative Cancer Inflammation Prognostic Index as a Superior Predictor of Short- and Long-Term Outcomes in Patients with Stage I–III Colorectal Cancer after Curative Surgery
Jeng-Fu You, Yu-Jen Hsu, Yih-Jong Chern, Ching-Chung Cheng, Bor-Kang Jong, Chun-Kai Liao, Pao-Shiu Hsieh, Hung-Chih Hsu, Wen-Sy Tsai
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174 Associations of DNA Base Excision Repair and Antioxidant Enzyme Genetic Risk Scores with Biomarker of Systemic Inflammation
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Frontiers in Aging. 2022; 3
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175 The Relationship Between Systemic Immune Inflammatory Index and Prognosis of Patients With Non-Small Cell Lung Cancer: A Meta-Analysis and Systematic Review
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Frontiers in Surgery. 2022; 9
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176 Prognostic significance of the systemic immune inflammation index in patients with metastatic and unresectable pancreatic cancer
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Frontiers in Surgery. 2022; 9
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177 Thiamine Demonstrates Bio-Preservative and Anti-Microbial Effects in Minced Beef Meat Storage and Lipopolysaccharide (LPS)-Stimulated RAW 264.7 Macrophages
Anis Ben Hsouna, Alex Boye, Bouthaina Ben Ackacha, Wissal Dhifi, Rania Ben Saad, Faiçal Brini, Wissem Mnif, Miroslava Kacániová
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178 Alcohol and Head and Neck Cancer: Updates on the Role of Oxidative Stress, Genetic, Epigenetics, Oral Microbiota, Antioxidants, and Alkylating Agents
Giampiero Ferraguti, Sergio Terracina, Carla Petrella, Antonio Greco, Antonio Minni, Marco Lucarelli, Enzo Agostinelli, Massimo Ralli, Marco de Vincentiis, Giammarco Raponi, Antonella Polimeni, Mauro Ceccanti, Brunella Caronti, Maria Grazia Di Certo, Christian Barbato, Alessandro Mattia, Luigi Tarani, Marco Fiore
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179 Flaxseed Ethanol Extracts’ Antitumor, Antioxidant, and Anti-Inflammatory Potential
Elisabeta Ioana Chera, Raluca Maria Pop, Marcel Pârvu, Olga Sori?au, Ana Uifalean, Florinela Adriana Catoi, Andra Cecan, Andrada Gabriela Negoescu, Patriciu Achima?-Cadariu, Alina Elena Pârvu
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180 Discovery of New Triterpenoids Extracted from Camellia oleifera Seed Cake and the Molecular Mechanism Underlying Their Antitumor Activity
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181 The emerging double-edged sword role of Sirtuins in the gastric inflammation-carcinoma sequence revealed by bulk and single-cell transcriptomes
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Frontiers in Oncology. 2022; 12
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182 An Optimized Two-Herb Chinese Food as Medicine Formula Reduces Cisplatin-Induced Nephrotoxicity in the Treatment of Lung Cancer in Mice
Le Shi, Yang Shu, Xiangdong Hu, Waheed Akram, Jun Wang, Shuang Dong, Biaobiao Luo, Jiuliang Zhang, Sheng Hu, Xiaohua Li, Xuebo Hu
Frontiers in Pharmacology. 2022; 13
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183 A Review on the Ethnopharmacology and Phytochemistry of the Neotropical Sages (Salvia Subgenus Calosphace; Lamiaceae) Emphasizing Mexican Species
Nancy Ortiz-Mendoza, Eva Aguirre-Hernández, Itzi Fragoso-Martínez, María Eva González-Trujano, Francisco A. Basurto-Peña, Martha J. Martínez-Gordillo
Frontiers in Pharmacology. 2022; 13
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184 Gut microbiota-derived metabolites in inflammatory diseases based on targeted metabolomics
Hui Xu, Li-Bin Pan, Hang Yu, Pei Han, Jie Fu, Zheng-Wei Zhang, Jia-Chun Hu, Xin-Yu Yang, Adili Keranmu, Hao-Jian Zhang, Meng-Meng Bu, Jian-Dong Jiang, Yan Wang
Frontiers in Pharmacology. 2022; 13
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185 The regulatory role of PDE4B in the progression of inflammatory function study
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Frontiers in Pharmacology. 2022; 13
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186 Understanding and harnessing triple-negative breast cancer-related microbiota in oncology
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Frontiers in Oncology. 2022; 12
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187 Current insights into the regulation of programmed cell death by TP53 mutation in cancer
Yali Su, Yingying Sai, Linfeng Zhou, Zeliang Liu, Panyan Du, Jinghua Wu, Jinghua Zhang
Frontiers in Oncology. 2022; 12
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188 Novel Diagnostic and Prognostic Tools for Lung Cancer Cachexia: Based on Nutritional and Inflammatory Status
Chen-An Liu, Qi Zhang, Guo-Tian Ruan, Liu-Yi Shen, Hai-Lun Xie, Tong Liu, Meng Tang, Xi Zhang, Ming Yang, Chun-Lei Hu, Kang-Ping Zhang, Xiao-Yue Liu, Han-Ping Shi
Frontiers in Oncology. 2022; 12
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189 Peripheral tuberculin purified protein derivative specific T cell immunoreactivity dynamics in non-muscle invasive bladder cancer patients receiving bacillus Calmette-Guerin instillation treatment
Huangqi Duan, Weimin Xia, Ding Xu, Yingying Chen, Yu Ding, Chen Wang, Ruiming Sun, Chengcheng Yao, Shun Zhang, Yu Wu, Ping Ji, Shujun Wang, Subo Qian, Ying Wang, Haibo Shen
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190 Prognostic Significance of the Systemic Immune-Inflammation Index in Patients With Cholangiocarcinoma: A Meta-Analysis
Xue-chun Liu, Yue-ping Jiang, Xue-guo Sun, Jian-jian Zhao, Ling-yun Zhang, Xue Jing
Frontiers in Oncology. 2022; 12
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191 Non-coding RNA in cancer drug resistance: Underlying mechanisms and clinical applications
Xuehao Zhou, Xiang Ao, Zhaojun Jia, Yiwen Li, Shouxiang Kuang, Chengcheng Du, Jinyu Zhang, Jianxun Wang, Ying Liu
Frontiers in Oncology. 2022; 12
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192 The association between biomarkers of acrylamide and cancer mortality in U.S. adult population: Evidence from NHANES 2003-2014
Wenbo Gu, Jiacheng Zhang, Chunling Ren, Yang Gao, Tongfang Zhang, Yujia Long, Wei Wei, Shaoying Hou, Changhao Sun, Changhong Wang, Wenbo Jiang, Junfei Zhao
Frontiers in Oncology. 2022; 12
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193 FTO promotes liver inflammation by suppressing m6A mRNA methylation of IL-17RA
Xiaojie Gan, Zhihui Dai, Chunmei Ge, Haozan Yin, Yuefan Wang, Jian Tan, Shuhan Sun, Weiping Zhou, Shengxian Yuan, Fu Yang
Frontiers in Oncology. 2022; 12
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194 Association between the empirical dietary inflammatory index and cardiorespiratory fitness in Tehranian adults in 2017–2018
Nastaran Payandeh, Hossein Shahinfar, Nadia Babaei, Samira Davarzani, Mojdeh Ebaditabar, Kurosh Djafarian, Sakineh Shab-Bidar
Frontiers in Nutrition. 2022; 9
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195 Associations of intermuscular adipose tissue and total muscle wasting score in PG-SGA with low muscle radiodensity and mass in nonmetastatic colorectal cancer: A two-center cohort study
Yang Wang, Yuliuming Wang, Guodong Li, Hao Zhang, Hang Yu, Jun Xiang, Zitong Wang, Xia Jiang, Guoqing Yan, Yunxiao Liu, Chunlin Wang, Huan Xiong, Guiyu Wang, Hanping Shi, Ming Liu
Frontiers in Nutrition. 2022; 9
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196 Risk of Colorectal Cancer in Patients With Irritable Bowel Syndrome: A Meta-Analysis of Population-Based Observational Studies
Xinhui Wu, Jingxi Wang, Zhen Ye, Jin Wang, Xibei Liao, Mengsi Liv, Zhen Svn
Frontiers in Medicine. 2022; 9
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197 Helicobacter pylori-Mediated Oxidative Stress and Gastric Diseases: A Review
Lu Han, Xu Shu, Jian Wang
Frontiers in Microbiology. 2022; 13
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198 The Systemic Inflammation Response Index as an Independent Predictor of Survival in Breast Cancer Patients: A Retrospective Study
Mengliu Zhu, Li Chen, Xiangyi Kong, Xiangyu Wang, Yi Fang, Xingrui Li, Jing Wang
Frontiers in Molecular Biosciences. 2022; 9
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199 Pro-Resolving Factor Administration Limits Cancer Progression by Enhancing Immune Response Against Cancer Cells
Audrey Wetzel, Francis Bonnefoy, Cécile Chagué, Mathieu Vetter, Mélanie Couturier, Blandine Baffert, Olivier Adotévi, Philippe Saas, Sylvain Perruche
Frontiers in Immunology. 2022; 12
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200 Berberine a traditional Chinese drug repurposing: Its actions in inflammation-associated ulcerative colitis and cancer therapy
Cuipeng Zhu, Kaiqi Li, Xiao-Xu Peng, Tong-Jia Yao, Zi-Yu Wang, Ping Hu, Demin Cai, Hao-Yu Liu
Frontiers in Immunology. 2022; 13
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201 Malassezia in Inflammatory Bowel Disease: Accomplice of Evoking Tumorigenesis
Qiyu Yang, Jing Ouyang, Damao Pi, Li Feng, Jiadan Yang
Frontiers in Immunology. 2022; 13
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202 Epigenetic Alterations and Inflammation as Emerging Use for the Advancement of Treatment in Non-Small Cell Lung Cancer
Shuo Yang, Yang Huang, Qi Zhao
Frontiers in Immunology. 2022; 13
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203 Single Cell RNA Sequencing Reveals the Pathogenesis of Aortic Dissection Caused by Hypertension and Marfan Syndrome
Li Zhang, Zhihuang Qiu, Hui Zheng, Xi Yang, Jianqiang Ye, Jian He, Yumei Li, Liangwan Chen
Frontiers in Cell and Developmental Biology. 2022; 10
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204 Focus on the tumor microenvironment: A seedbed for neuroendocrine prostate cancer
Hengfeng Zhou, Qiangrong He, Chao Li, Bassam Lutf Mohammed Alsharafi, Liang Deng, Zhi Long, Yu Gan
Frontiers in Cell and Developmental Biology. 2022; 10
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205 The SIRT1-HMGB1 axis: Therapeutic potential to ameliorate inflammatory responses and tumor occurrence
Lanyi Wei, Wenrui Zhang, Yueyang Li, Jinghui Zhai
Frontiers in Cell and Developmental Biology. 2022; 10
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206 Anti-inflammatory sesquiterpene and triterpene acids from Mesona procumbens Hemsley
Hung-Tse Huang, I-Wen Lo, Geng-You Liao, Yu-Chi Lin, Yuh-Chiang Shen, Hui-Chi Huang, Tsung-Lin Li, Kung-Ta Lee, Yao-Haur Kuo, Chia-Ching Liaw
Frontiers in Chemistry. 2022; 10
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207 Etodolac Enhances the Radiosensitivity of Irradiated HT-29 Human Colorectal Cancer Cells
Zahra Shaghaghi, Nasim Zarei Polgardani, Sahar Abbasi, Hajar Albooyeh, Leila Dastranj, Soghra Farzipour, Maryam Alvandi
Current Radiopharmaceuticals. 2022; 15(3): 242
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208 Nomogram Based on Inflammatory Biomarkers and Nutritional Indicators for Predicting Overall Survival in Locoregionally Advanced Nasopharyngeal Carcinoma
Rong Zhao, Zhongguo Liang, Kaihua Chen, Xiaodong Zhu
Journal of Inflammation Research. 2022; Volume 15: 2971
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209 Corosolic Acid Inhibits Secretory Phospholipase A2IIa as an Anti-Inflammatory Function and Exhibits Anti-Tumor Activity in Ehrlich Ascites Carcinoma Bearing Mice
Sophiya Pundalik, Krishna Ram Hanumappa, Aladahalli S Giresha, Deepadarshan Urs, Sharath Rajashekarappa, Narayanappa Muniyappa, Manjunatha Jamballi G, Devaraju Kuaramkote Shivanna, Rajkumar S Meti, Sathisha Anekere Dasappa Setty, Prabhakar Bettadathunga? Thippegowda, Dharmappa Kattepura Krishnappa
Journal of Inflammation Research. 2022; Volume 15: 6905
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210 Clinical Significance of Peripheral Blood Lymphocyte Subtypes and Cytokines in Patients with Hepatocellular Carcinoma Treated with TACE
Hongyu Wang, Guixiong Zhang, Wenzhe Fan, Yanqin Wu, Jiang Zhang, Miao Xue, Yue Zhao, Wang Yao, Jiaping Li
Cancer Management and Research. 2022; Volume 14: 451
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211 The Systemic Immune-Inflammation Index is an Independent Predictor of Survival in Breast Cancer Patients
Mengliu Zhu, Li Chen, Xiangyi Kong, Xiangyu Wang, Xingrui Li, Yi Fang, Jing Wang
Cancer Management and Research. 2022; Volume 14: 775
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212 Malnutrition in oncology: etiology, pathogenesis, and principles of correction
Denis Tsvetkov
Clinical nutrition and metabolism. 2022;
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213 A Genomic Approach to Identify the Different between Acute and Chronic UVB Exposures in the Causation of Inflammation and Cancer
JunPyo Han, Yujin Jang, Dong Yeop Shin, Jun Lee, Young Rok Seo
Journal of Cancer Prevention. 2022; 27(4): 199
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214 Metformin and malignant neoplasms: a possible mechanism of antitumor action and prospects for use in practice
K. O. Kuznetsov, E. R. Safina, D. V. Gaimakova, Ya. S. Frolova, I. Yu. Oganesyan, A. G. Sadertdinova, K. A. Nazmieva, A. H. Islamgulov, A. R. Karimova, A. M. Galimova, E. V. Rizvanova
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215 Correlation between 4 Inflammatory Indicators and Prognosis of Patients with Stage III Breast Cancer
?? ?
Advances in Clinical Medicine. 2022; 12(11): 10168
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216 Research Progress of Common Thyroid Diseases and Systemic Immune Inflammation Index
? ?
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217 Ajania purpurea Extract Attenuates LPS-Induced Inflammation in RAW264.7 Cells and Peritonitis Mice
Xiangyu Wang, Zhuoma Dongzhi, Yan Li, Mi Xie, Xinyu Li, Ruiying Yuan, Bin Li, Pharkphoom Panichayupakaranant, Shan Huang
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218 C-reactive protein and white blood cell are associated with frailty progression: a longitudinal study
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Immunity & Ageing. 2022; 19(1)
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219 The prognostic value of the advanced lung cancer inflammation index (ALI) for patients with neuroblastoma
Can Qi, Yun Zhou, Zhonghui Hu, Huizhong Niu, Fang Yue, Huibo An, Zhiguo Chen, Ping Wang, Le Wang, Guochen Duan
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220 FADD as a key molecular player in cancer progression
Ying Liu, Xiaoge Li, Xuehao Zhou, Jianxun Wang, Xiang Ao
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221 Identification of inflammatory-related gene signatures to predict prognosis of endometrial carcinoma
Linlin Chen, Guang Zhu, Yanbo Liu, Yupei Shao, Bing Pan, Jianhong Zheng
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222 Circulating lymphocyte subsets are prognostic factors in patients with nasopharyngeal carcinoma
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223 Dynamic changes in the systemic immune-inflammation index predict the prognosis of EGFR-mutant lung adenocarcinoma patients receiving brain metastasis radiotherapy
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224 Anti-Inflammatory Effects of Coumarin–Selenophene Derivatives on LPS-Stimulated RAW 264.7 Macrophage Cells
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225 Solubilization and In Vitro Physical and Chemical Properties of the Amorphous Spray-Dried Lactose-Luteolin System
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226 A Novel Inflammation-Related Gene Signature for Overall Survival Prediction and Comprehensive Analysis in Pediatric Patients with Wilms Tumor
Jiahao Zhang, Yongchang Lai, Langjing Zhu, Zechao Lu, Chuxian Hu, Haobin Zhou, Zeguang Lu, Zhicheng Tang, Zhaohui He, Fucai Tang, Jayaraman Tharmalingam
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227 Managing Cancer Drug Resistance from the Perspective of Inflammation
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228 Sesquiterpene Lactones and Cancer: New Insight into Antitumor and Anti-inflammatory Effects of Parthenolide-Derived Dimethylaminomicheliolide and Micheliolide
Yubo Dong, Xuanjin Qian, Jian Li, Ahmed Faeq Hussein
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229 Relationship between PLR and Clinicopathological Characteristics of Patients with Advanced NSCLC and Its Predictive Value for the Efficacy of Chemotherapy and Prognosis
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230 Exploring the Multicomponent Synergy Mechanism of Yinzhihuang Granule in Inhibiting Inflammation-Cancer Transformation of Hepar Based on Integrated Bioinformatics and Network Pharmacology
Jingyuan Zhang, Zhihong Huang, Xinkui Liu, Chao Wu, Wei Zhou, Peizhi Ye, Antony Stalin, Shan Lu, Yingying Tan, Zhishan Wu, Xiaotian Fan, Xiaomeng Zhang, Miaomiao Wang, Bingbing Li, Guoliang Cheng, Yanfang Mou, Jiarui Wu, Shibiao Wan
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231 Arsenic Induces Continuous Inflammation and Regulates Th1/Th2/Th17/Treg Balance in Liver and Kidney In Vivo
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232 Prostaglandin Pathways: Opportunities for Cancer Prevention and Therapy
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233 Palatal soft tissue thickness around dental implants and natural teeth in health and disease: A cross sectional study
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234 Date fruit as a promising source of functional carbohydrates and bioactive compounds: A review on its nutraceutical potential
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235 Evidence that the anti-inflammatory effect of 4-aryl-4 H -chromenes is linked to macrophage repolarization
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236 Benzimidazole derivatives: A versatile scaffold for drug development against Helicobacter pylori -related diseases
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237 Subacute exposure to bisphenol F diglycidyl-ether induces chronic dermatitis characterized by psoriasis-like skin inflammation in mice
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238 Prognostic significance of gamma-glutamyl transpeptidase to albumin ratio in patients with intrahepatic cholangiocarcinoma after hepatectomy
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239 Corneodesmosin as a potential target of oral squamous cell carcinoma
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240 Serum amyloid A (SAA) and Interleukin-6 (IL-6) as the potential biomarkers for gastric cancer
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241 Local and systemic inflammation triggers different outcomes of tumor growth related to infiltration of anti-tumor or pro-tumor macrophages
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242 Health Economics Research in Primary Prevention of Cancer: Assessment, Current Challenges, and Future Directions
Donatus U Ekwueme, Michael T Halpern, Harrell W Chesson, Mahima Ashok, Jeffrey Drope, Young-Rock Hong, Michael Maciosek, Michael F Pesko, Donald S Kenkel
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243 Ramelteon and mechanism of its restorative effect in an experimental lung disease model
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244 Beta-carotene regulates the biological activity of EGF in IEC6 cells by alleviating the inflammatory process
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245 Flavonoids in vegetables: improvement of dietary flavonoids by metabolic engineering to promote health
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246 Bee pollen in zebrafish diet affects intestinal microbiota composition and skin cutaneous melanoma development
Isabela M. Di Chiacchio, Elena Gómez-Abenza, Isadora M. Paiva, Danilo J. M. de Abreu, Juan Francisco Rodríguez-Vidal, Elisângela E. N. Carvalho, Stephan M. Carvalho, Luis David Solis-Murgas, Victoriano Mulero
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247 Pancreatic adenocarcinoma associated immune-gene signature as a novo risk factor for clinical prognosis prediction in hepatocellular carcinoma
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248 Cancer stem cells induced by chronic stimulation with prostaglandin E2 exhibited constitutively activated PI3K axis
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249 Oxidative stress induces meiotic defects of oocytes in a mouse psoriasis model
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250 Emerging mechanisms of pyroptosis and its therapeutic strategy in cancer
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251 Correlation analysis of lymphocyte-monocyte ratio with pathological complete response and clinical prognosis of neoadjuvant chemotherapy in patients with breast cancer
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252 Preoperative systemic inflammation response index indicates poor prognosis in patients treated with resection of renal cell carcinoma with inferior vena cava tumor thrombus
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253 Comprehensive molecular analysis of a four-pyroptosis-gene signature with prognosis and immune landscape in lung adenocarcinoma
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254 Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review
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255 Detection of IL-1ß, VEGF and IL-4 with Their Novel Genetic Variations in Breast Cancer Patients
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256 A review on inflammation and angiogenesis as key mechanisms involved in the pathogenesis of bovine cystic ovarian disease
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257 Can a basic solution activate the inflammatory reflex? A review of potential mechanisms, opportunities, and challenges
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258 Recent Progress in Cancer Immunotherapy: Overview of Current Status and Challenges
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259 Prognostic Significance of Lab Data and Performance Comparison by Validating Survival Prediction Models for Patients with Spinal Metastases After Radiotherapy
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260 Curcumin: A therapeutic strategy for targeting the Helicobacter pylori-related diseases
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261 Resolvins lipid mediators: Potential therapeutic targets in Alzheimer and Parkinson disease
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262 Modulation of biomarkers associated with risk of cancer in humans by olive oil intake: A systematic review
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263 Interleukin-38 in Health and Disease
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264 Living Cell for Drug Delivery
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265 Balancing functional and health benefits of food products formulated with palm oil as oil sources
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266 Emerging roles of hnRNP A2B1 in cancer and inflammation
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267 Seasonality impact on the anti-inflammatory, antiproliferative potential and the lignan composition of Bursera microphylla
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268 Mechanistic insight into the synergism of IL-27 and IL-28B in regulation of benzo(a)pyrene-induced lung carcinogenesis associated ROS/NF-?B/NLRP3 crosstalk
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270 Pterostilbene supresses inflammation-induced melanoma metastasis by impeding neutrophil elastase-mediated thrombospondin-1 degradation
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271 Multiple approaches to repurposing drugs for neuroblastoma
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272 From hurdle to springboard: The macrophage as target in biomaterial-based bone regeneration strategies
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273 Lifestyle and environmental factors may induce airway and systemic inflammation in firefighters
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274 Exploring the underlying mechanism of oleanolic acid treating glioma by transcriptome and molecular docking
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275 Drug Metabolite Cluster Centers-based Strategy for Comprehensive Profiling of Neomangiferin Metabolites in vivo and in vitro and Network Pharmacology Study on Anti-inflammatory Mechanism
Xianming Lan, Yanan Li, Haoran Li, Shuyi Song, Xiaoqing Yuan, Hongyan Zhou, Qimei Chen, Jiayu Zhang
Arabian Journal of Chemistry. 2022; : 104268
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276 Anticancer Effect of Ruscogenin in B(a)P-Induced Lung Cancer in Mice via Modulation of Proinflammatory Cytokines and Mitochondrial Enzymes
Jun Zhao, Bangzhi He, Vidya Devanathadesikan Seshadri, Shaohua Xu
Applied Biochemistry and Biotechnology. 2022;
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277 Immune cell–camouflaged surface-engineered nanotherapeutics for cancer management
Naitik Jain, Syed Shahrukh, Paras Famta, Saurabh Shah, Ganesh Vambhurkar, Dharmendra Kumar Khatri, Shashi Bala Singh, Saurabh Srivastava
Acta Biomaterialia. 2022;
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278 The role of inflammations and EMT in carcinogenesis
Md Shariful Islam, Md Reaz Morshed, Golap Babu, Md Asaduzzaman Khan
Advances in Cancer Biology - Metastasis. 2022; 5: 100055
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279 Prognostic assessment of C-reactive protein and neutrophil to lymphocyte ratio in patients with non-small cell lung cancer
Tingting Zhao
Wiener klinische Wochenschrift. 2022;
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280 Role of chemokine systems in cancer and inflammatory diseases
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MedComm. 2022; 3(2)
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281 Beneficial effects of Ginkgo biloba leaf extract on inflammatory markers: A systematic review and meta-analysis of the clinical trials
Seyedeh Neda Mousavi, Mahboobe Hosseinikia, Esmaeil Yousefi Rad, Somayeh Saboori
Phytotherapy Research. 2022;
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282 Dynamic changes of soluble HLA-G and cytokine plasma levels in cervical cancer patients: potential role in cancer progression and immunotherapy
Hui-Hui Xu, You-You Xie, Jun-Gan, Zhi Yang, Qiu-Yue Han
Journal of Cancer Research and Clinical Oncology. 2022;
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283 Obesity, cancer risk, and time-restricted eating
Manasi Das, Nicholas J. G. Webster
Cancer and Metastasis Reviews. 2022;
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284 Chloroxylon swietenia (Roxb.) DC induces cell death and apoptosis by down-regulating the NF-?B pathway in MCF -7 breast cancer cells: In vitro and in vivo inv
Sonali S. Kamble, Jasoda Choudhari, Ramakrishna Nimma, Totakura Venkata Santosh Kumar, Kapil K. Patil, Shrikant V. Hese, Bhaskar S. Dawane, Rajesh N. Gacche
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285 Regulator of telomere elongation helicase 1 gene and its association with malignancy
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286 Inhibiting AKT signaling pathway with cilostazol and meloxicam synergism for suppressing K562 cells in vitro
Laya Naderbar, Yaghub Pazhang, Jafar Rezaie
Journal of Biochemical and Molecular Toxicology. 2022;
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287 Screening and isolation of potential lipoxidase and superoxide dismutase inhibitors from Scutellaria baicalensis Georgi using high-speed countercurrent chromatography target-guided by ultrafiltration-liquid chromatogra
Jianli Xia, Chunming Liu, Huazhou Niu, Wanchao Hou, Sainan Li
Journal of Separation Science. 2021; 44(7): 1371
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288 Analyzing the influence of IL18 in regulation of YAP1 in breast oncogenesis using cBioportal
Ayesha Rahman, Lingadahalli S. Shashidhara
Cancer Reports. 2021;
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289 Calprotectin in viral systemic infections—COVID-19 versus hepatitis C virus
Letitia Toma, Mihai Dodot, Anca Zgura, Nicolae Bacalbasa, Andrei Silaghi, Razvan Simu, Teodora Isac, Adriana Mercan-Stanciu
Clinical and Experimental Medicine. 2021;
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290 Anti-neoplastic phramacophore benzophenone-1 coumarin (BP-1C) targets JAK2 to induce apoptosis in lung cancer
Ankith Sherapura, Vikas H. Malojirao, Prabhu Thirusangu, B. S. Sharath, Shivananda Kandagalla, V. Vigneshwaran, Jurica Novak, Lakshmi Ranganatha, Y. L. Ramachandra, Shrinath M. Baliga, Shaukath Ara Khanum, B. T. Prabhakar
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291 Cure lies in nature: medicinal plants and endophytic fungi in curbing cancer
Garima Tyagi, Neha Kapoor, Girish Chandra, Lokesh Gambhir
3 Biotech. 2021; 11(6)
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292 The role of Wnt pathway in obesity induced inflammation and diabetes: a review
Bhabajyoti Das, Manas Das, Anuradha Kalita, Momita Rani Baro
Journal of Diabetes & Metabolic Disorders. 2021;
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293 Unboxing the molecular modalities of mutagens in cancer
Smita Kumari, Sudhanshu Sharma, Dia Advani, Akanksha Khosla, Pravir Kumar, Rashmi K. Ambasta
Environmental Science and Pollution Research. 2021;
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294 Elastin-Derived Peptides in the Central Nervous System: Friend or Foe
Konrad A. Szychowski, Bartosz Skóra, Anna K. Wójtowicz
Cellular and Molecular Neurobiology. 2021;
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295 Synthesis of 6-epi-tuberiferin and the biological activities of tuberiferin, dehydrobrabrachylaenolide, 6-epi-tuberiferin, and their synthetic intermediates
Dan Li, Yohsuke Higuchi, Takafumi Kobayashi, Fumito Shimoma, Yuhua Bai, Masayoshi Ando
Bioorganic Chemistry. 2021; 108: 104642
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296 The effect of medications associated with drug-induced pancreatitis on pancreatic cancer risk: A nested case-control study of routine Scottish data
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Cancer Epidemiology. 2021; 71: 101880
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297 Trans-anethole Attenuates Diet-induced Nonalcoholic Steatohepatitis Through Suppressing TGF-ß-mediated Fibrosis
Caicai Zhang, Baoyong Zhang, Aifang Chen, Qiling Yin, Haixia Wang
Clinics and Research in Hepatology and Gastroenterology. 2021; : 101833
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298 Long non-coding RNAs regulate the hallmarks of cancer in HPV-induced malignancies
Tânia R. Dias, Joana M.O. Santos, Rui M. Gil da Costa, Rui Medeiros
Critical Reviews in Oncology/Hematology. 2021; 161: 103310
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299 The diverse roles of TMEM16A Ca2+-activated Cl- channels in inflammation
Weiliang Bai, Mei Liu, Qinghuan Xiao
Journal of Advanced Research. 2021; 33: 53
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300 Analgesic and anti-inflammatory articular effects of essential oil and camphor isolated from Ocimum kilimandscharicum Gürke leaves
Elisangela dos Santos, Maicon Matos Leitão, Caren Naomi Aguero Ito, Saulo Euclides Silva-Filho, Arielle Cristina Arena, Francielli Maria de Souza Silva-Comar, Roberto Kenji Nakamura Cuman, Rodrigo Juliano Oliveira, Anelise Samara Nazari Formagio, Cândida Aparecida Leite Kassuya
Journal of Ethnopharmacology. 2021; 269: 113697
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301 Prognostic value of preoperative inflammatory markers among different molecular subtypes of lower-grade glioma
Zengxin Qi, Jiajun Cai, Xiangda Meng, Shengyong Cai, Chao Tang, Liqin Lang
Journal of Clinical Neuroscience. 2021;
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302 Myosteatosis reduces overall survival in patients with digestive system malignancies: a meta-analysis with trial sequential analysis
Yue Wang, Guangwei Tian, Song Chen, Nan Li
Nutrition Research. 2021; 94: 25
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303 Is resistin the master link between inflammation and inflammation-related chronic diseases?
Mohammed Taouis, Yacir Benomar
Molecular and Cellular Endocrinology. 2021; 533: 111341
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304 Human gut-microbiome interplay: Analysis of clinical studies for the emerging roles of diagnostic microbiology in inflammation, oncogenesis and cancer management
Ziyu Jiang, Lingchang Li, Jianan Chen, Guoli Wei, Yi Ji, Xi Chen, Jingbing Liu, Jiege Huo
Infection, Genetics and Evolution. 2021; 93: 104946
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305 The potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine
Thi Thuy Tien Vo, Quang Canh Vo, Vo Phuoc Tuan, Yinshen Wee, Hsin-Chung Cheng, I-Ta Lee
Redox Biology. 2021; 46: 102124
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306 Anticancer Natural Products Targeting Immune Checkpoint Protein Network
Kyung-Soo Chun, Do-Hee Kim, Pawan Kumar Raut, Young-Joon Surh
Seminars in Cancer Biology. 2021;
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307 Pancreatitis initiated pancreatic ductal adenocarcinoma: Pathophysiology explaining clinical evidence
Xufeng Tao, Hong Xiang, Yue Pan, Dong Shang, Junchao Guo, Ge Gao, Gary Guishan Xiao
Pharmacological Research. 2021; 168: 105595
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308 How do green and black coffee brews and bioactive interaction with gut microbiome affect its health outcomes? Mining evidence from mechanistic studies, metagenomics and clinical trials
Mohamed A. Farag, Martin von Bergen, Basma M. Saleh, Masun Nabhan Homsi, Mohamed S. Abd El-Al
Trends in Food Science & Technology. 2021; 118: 920
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309 Nimbolide, a Neem Limonoid, Is a Promising Candidate for the Anticancer Drug Arsenal
Siddavaram Nagini, Ramesh Nivetha, Manikandan Palrasu, Rajakishore Mishra
Journal of Medicinal Chemistry. 2021; 64(7): 3560
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310 Comprehensive analysis reveals common DNA methylation patterns of tobacco-associated cancers: A pan-cancer analysis
Xingyu Liu, Jiarui Chen, Jiali Li, Zihang Zeng, Xueping Jiang, Yanping Gao, Zhengrong Huang, Qiuji Wu, Yan Gong, Conghua Xie
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311 The expression of FLNA and CLU in PBMCs as a novel screening marker for hepatocellular carcinoma
Rathasapa Patarat, Shoji Riku, Pattapon Kunadirek, Natthaya Chuaypen, Pisit Tangkijvanich, Apiwat Mutirangura, Charoenchai Puttipanyalears
Scientific Reports. 2021; 11(1)
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312 CPAP enhances and maintains chronic inflammation in hepatocytes to promote hepatocarcinogenesis
Ruo-Yu Chen, Chia-Jui Yen, Yih-Jyh Lin, Ju-Ming Wang, Ting-Fen Tasi, Yu-Chuan Huang, Yao-Wen Liu, Hung-Wen Tsai, Ming-Hao Lee, Liang-Yi Hung
Cell Death & Disease. 2021; 12(11)
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313 Carbon dots up-regulate heme oxygenase-1 expression towards acute lung injury therapy
Bo Wang, Peipei Liu, Hui Huang, Xiting Wang, Mengling Zhang, Jian Huang, Fang Lu, Jian Chen, Yang Liu, Zhenhui Kang
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314 Proteases, protease inhibitors and radiation carcinogenesis
Ann R. Kennedy
International Journal of Radiation Biology. 2021; : 1
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315 Amomum subulatum Induces Apoptosis in Tumor Cells and Reduces Tumor Burden in Experimental Animals via Modulating Pro-Inflammatory Cytokines
Drishya Sudarsanan, Dhanisha Suresh Sulekha, Guruvayoorappan Chandrasekharan
Cancer Investigation. 2021; : 1
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316 Anti-inflammatory effect of Barringtonia angusta methanol extract is mediated by targeting of Src in the NF-?B signalling pathway
Minkyeong Jo, Jongsung Lee, Han Gyung Kim, Jin Kyeong Kim, Haeyeop Kim, Kon Kuk Shin, Tran The Bach, Sang Mi Eum, Jong Sub Lee, Eui Su Choung, Yoonyong Yang, Kyung-Hee Kim, Gi-Ho Sung, Byong Chul Yoo, Jae Youl Cho
Pharmaceutical Biology. 2021; 59(1): 799
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317 Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review
Ming Bian, Qian-qian Ma, Yun Wu, Huan-huan Du, Gong Guo-hua
Journal of Enzyme Inhibition and Medicinal Chemistry. 2021; 36(1): 2139
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318 Chalcones against the hallmarks of cancer: a mini-review
Paloma Silva de Souza, Geysa Cristina Caldas Bibá, Evelynn Dalila do Nascimento Melo, Michelle Frazão Muzitano
Natural Product Research. 2021; : 1
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319 Mechanism of Kaempferol in Anti-inflammation Based on Network Pharmacology
Ping Qin, Hongmei Wu
IOP Conference Series: Earth and Environmental Science. 2021; 692(3): 032031
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320 The Effects of Almond Consumption on Inflammatory Biomarkers in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Shahin Fatahi, Elnaz Daneshzad, Keyhan Lotfi, Leila Azadbakht
Advances in Nutrition. 2021;
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321 Molecular mechanisms of anticancer activities of polyphyllin VII
Bashir Ahmad, Shafiq Ur Rehman, Azizullah Azizullah, Muhammad Fiaz Khan, Syed Riaz Ud Din, Manzoor Ahmad, Ashraf Ali, Naeem Tahir, Nasir Azam, Yaser Gamallat, Khalil Ur Rahman, Muhsin Ali, Mohammad Safi, Imran Khan, Samina Qamer, Deog-Hwan Oh
Chemical Biology & Drug Design. 2021; 97(4): 914
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322 Neutrophil-to-lymphocyte ratio is an independent prognostic marker for feline mammary carcinomas
Gonçalo N. Petrucci, Luís Lobo, Felisbina Queiroga, José Martins, Justina Prada, Isabel Pires, Joaquim Henriques
Veterinary and Comparative Oncology. 2021; 19(3): 482
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323 IL-9 and IL-10 Single-Nucleotide Variants and Serum Levels in Age-Related Macular Degeneration in the Caucasian Population
Alvita Vilkeviciute, Dzastina Cebatoriene, Loresa Kriauciuniene, Reda Zemaitiene, Rasa Liutkeviciene, Ayumi Ouchi
Mediators of Inflammation. 2021; 2021: 1
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324 The Uprising of Mitochondrial DNA Biomarker in Cancer
Siti Zulaikha Nashwa Mohd Khair, Siti Muslihah Abd Radzak, Abdul Aziz Mohamed Yusoff, Jie Mei
Disease Markers. 2021; 2021: 1
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325 Key Factor Regulating Inflammatory Microenvironment, Metastasis, and Resistance in Breast Cancer: Interleukin-1 Signaling
Fengjie Liu, Lihong Li, Meng Lan, Tengteng Zou, Zhaodi Kong, Tiange Cai, Xiao Yu Wu, Yu Cai, Matilde Otero-Losada
Mediators of Inflammation. 2021; 2021: 1
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326 The Ratio of Platelets to Lymphocytes Predicts the Prognosis of Metastatic Colorectal Cancer: A Review and Meta-Analysis
Jinming Wang, Jing Li, Sheng Wei, Jie Xu, Xiaohui Jiang, Lei Yang, Nicola Silvestris
Gastroenterology Research and Practice. 2021; 2021: 1
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327 High pretreatment systemic immune-inflammation index values are associated with diminished short-term success after temporomandibular joint arthrocentesis procedure
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BMC Oral Health. 2021; 21(1)
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328 The advanced lung cancer inflammation index predicts outcomes of patients with non-small cell lung cancer following video-assisted thoracic surgery
Zhaohui Han, Zhonghui Hu, Qingtao Zhao, Wenfei Xue, Guochen Duan
Journal of International Medical Research. 2021; 49(12): 0300060521
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329 Construction and prognostic analysis of miRNA-mRNA regulatory network in liver metastasis from colorectal cancer
Ruyun Cai, Qian Lu, Da Wang
World Journal of Surgical Oncology. 2021; 19(1)
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330 Human amniotic mesenchymal stem cells to promote/suppress cancer: two sides of the same coin
Ameneh Jafari, Mostafa Rezaei-Tavirani, Behrouz Farhadihosseinabadi, Hakimeh Zali, Hassan Niknejad
Stem Cell Research & Therapy. 2021; 12(1)
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331 Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment
Qiwei Yang, Michal Ciebiera, Maria Victoria Bariani, Mohamed Ali, Hoda Elkafas, Thomas G Boyer, Ayman Al-Hendy
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332 Availability of preoperative neutrophil-lymphocyte ratio to predict postoperative delirium after head and neck free-flap reconstruction: A retrospective study
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333 Cluster analysis of blood serum inflammation markers of conditionally healthy people
L. V. Androsova, A. N. Simonov, N. V. Ponomareva, T. P. Klyushnik
Medical Immunology (Russia). 2021; 23(2): 293
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334 Anti-inflammatory activities of arthropod peptides: a systematic review
Ariane Teixeira dos Santos, Gabriela Silva Cruz, Gandhi Rádis Baptista
Journal of Venomous Animals and Toxins including Tropical Diseases. 2021; 27
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335 The Preoperative Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio Predicts Disease-Free Survival in Resectable Esophageal Squamous Cell Carcinoma
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Cancer Management and Research. 2021; Volume 13: 7511
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336 Supervised Learning Based Systemic Inflammatory Markers Enable Accurate Additional Surgery for pT1NxM0 Colorectal Cancer: A Comparative Analysis of Two Practical Prediction Models for Lymph Node Metastasis
Jinlian Jin, Haiyan Zhou, Shulin Sun, Zhe Tian, Haibing Ren, Jinwu Feng
Cancer Management and Research. 2021; Volume 13: 8967
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337 Metformin and Malignant Tumors: Not Over the Hill
Weiling Leng, Juan Jiang, Bing Chen, Qinan Wu
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2021; Volume 14: 3673
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338 Current Trends and Challenges in Pharmacoeconomic Aspects of Nanocarriers as Drug Delivery Systems for Cancer Treatment
Sylwia Milewska, Katarzyna Niemirowicz-Laskowska, Gabriela Siemiaszko, Piotr Nowicki, Agnieszka Z Wilczewska, Halina Car
International Journal of Nanomedicine. 2021; Volume 16: 6593
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339 GDC-0575, a CHK1 Inhibitor, Impairs the Development of Colitis and Colitis-Associated Cancer by Inhibiting CCR2+ Macrophage Infiltration in Mice
Min Li, Tianqing Huang, Xiaolan Li, Zhiwei Shi, Yue Sheng, Mimi Hu, Kui Song
OncoTargets and Therapy. 2021; Volume 14: 2661
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340 Preoperative Serum Hypersensitive-c-Reactive-Protein (Hs-CRP) to Albumin Ratio Predicts Survival in Patients with Luminal B Subtype Breast Cancer
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OncoTargets and Therapy. 2021; Volume 14: 4137
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341 Fibrinogen/Albumin Ratio (FAR) in Patients with Triple Negative Breast Cancer and Its Relationship with Epidermal Growth Factor Receptor Expression
Wenbo Gao, Ming Li, Yunhao Zhang
OncoTargets and Therapy. 2021; Volume 14: 5403
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342 Pretreatment Systemic Immune-Inflammation Index Predict Needs for Teeth Extractions for Locally Advanced Head and Neck Cancer Patients Undergoing Concurrent Chemoradiotherapy
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Therapeutics and Clinical Risk Management. 2021; Volume 17: 1113
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343 Risk Factors Associated with Prostate Cancer
Arslan Habib, Ghulam Jaffar, Malik ShahZaib Khalid, Zahid Hussain, Syeda Wafa Zainab, Zeeshan Ashraf, Atia Haroon, Rimsha Javed, Bilal Khalid, Palwasha Habib
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344 Inflammation and Wnt Signaling: Target for Immunomodulatory Therapy?
Imen Jridi, Kirsten Canté-Barrett, Karin Pike-Overzet, Frank J. T. Staal
Frontiers in Cell and Developmental Biology. 2021; 8
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345 A Mechanism Leading to Changes in Copy Number Variations Affected by Transcriptional Level Might Be Involved in Evolution, Embryonic Development, Senescence, and Oncogenesis Mediated by Retrotransposons
Yunpeng Sui, Shuanghong Peng
Frontiers in Cell and Developmental Biology. 2021; 9
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346 Tumor-Associated Extracellular Matrix: How to Be a Potential Aide to Anti-tumor Immunotherapy?
Yingying He, Tao Liu, Shuang Dai, Zihan Xu, Li Wang, Feng Luo
Frontiers in Cell and Developmental Biology. 2021; 9
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347 The relationship of pre-operative laboratory parameters with endometrial cancer and prognostic factors
Süleyman Serkan KARASIN, Burak AKSELIM
Journal of Surgery and Medicine. 2021; 5(4): 344
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348 The Role of Tumor Inflammatory Microenvironment in Lung Cancer
Zhaofeng Tan, Haibin Xue, Yuli Sun, Chuanlong Zhang, Yonglei Song, Yuanfu Qi
Frontiers in Pharmacology. 2021; 12
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349 Aging, Osteo-Sarcopenia, and Musculoskeletal Mechano-Transduction
Jenna M. Leser, Anicca Harriot, Heather V. Buck, Christopher W. Ward, Joseph P. Stains
Frontiers in Rehabilitation Sciences. 2021; 2
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350 The Crossroads of Periodontitis and Oral Squamous Cell Carcinoma: Immune Implications and Tumor Promoting Capacities
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Frontiers in Oral Health. 2021; 1
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351 Leptin, Both Bad and Good Actor in Cancer
Carlos Jiménez-Cortegana, Ana López-Saavedra, Flora Sánchez-Jiménez, Antonio Pérez-Pérez, Jesús Castiñeiras, Juan A. Virizuela-Echaburu, Luis de la de la Cruz-Merino, Víctor Sánchez-Margalet
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352 From Allergy to Cancer—Clinical Usefulness of Eotaxins
Monika Zajkowska, Barbara Mroczko
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353 Association of Genetic Polymorphisms and Serum Levels of IL-6 and IL-8 with the Prognosis in Children with Neuroblastoma
Silvia Selene Moreno-Guerrero, Arturo Ramírez-Pacheco, Luz María Rocha-Ramírez, Gabriela Hernández-Pliego, Pilar Eguía-Aguilar, María Argelia Escobar-Sánchez, Alfonso Reyes-López, Luis Enrique Juárez-Villegas, Juan José Luis Sienra-Monge
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354 The Role of Bacteria in KSHV Infection and KSHV-Induced Cancers
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355 Potential of Bioactive Food Components against Gastric Cancer: Insights into Molecular Mechanism and Therapeutic Targets
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356 Molecular Markers to Predict Prognosis and Treatment Response in Uterine Cervical Cancer
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357 Insights of RKIP-Derived Suppression of Prostate Cancer
Ying Dong, Xiaozeng Lin, Anil Kapoor, Yan Gu, Hui Xu, Pierre Major, Damu Tang
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358 Natural and Synthetic Estrogens in Chronic Inflammation and Breast Cancer
Chandra K. Maharjan, Jiao Mo, Lei Wang, Myung-Chul Kim, Sameul Wang, Nicholas Borcherding, Praveen Vikas, Weizhou Zhang
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359 NUB1 and FAT10 Proteins as Potential Novel Biomarkers in Cancer: A Translational Perspective
Maria Arshad, Nazefah Abdul Hamid, Mun Chiang Chan, Fuad Ismail, Geok Chin Tan, Francesco Pezzella, Ka-Liong Tan
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360 Molecular Action of Polyphenols in Leukaemia and Their Therapeutic Potential
Hamza A. Alaswad, Amani A. Mahbub, Christine L. Le Maitre, Nicola Jordan-Mahy
International Journal of Molecular Sciences. 2021; 22(6): 3085
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361 RAAS: A Convergent Player in Ischemic Heart Failure and Cancer
Texali C. Garcia-Garduño, Jorge R. Padilla-Gutierrez, Diego Cambrón-Mora, Yeminia Valle
International Journal of Molecular Sciences. 2021; 22(13): 7106
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362 Therapeutic Potential of Jasmonic Acid and Its Derivatives
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363 An Insight into Anti-Inflammatory Activities and Inflammation Related Diseases of Anthocyanins: A Review of Both In Vivo and In Vitro Investigations
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364 The Role of the Immune System in IBD-Associated Colorectal Cancer: From Pro to Anti-Tumorigenic Mechanisms
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365 Nutraceuticals and Cancer: Potential for Natural Polyphenols
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366 Receptor-Interacting Serine/Threonine-Protein Kinase-2 as a Potential Prognostic Factor in Colorectal Cancer
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367 Jasmonate Compounds and Their Derivatives in the Regulation of the Neoplastic Processes
Iwona Jarocka-Karpowicz, Agnieszka Markowska
Molecules. 2021; 26(10): 2901
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368 Sweet Cherries as Anti-Cancer Agents: From Bioactive Compounds to Function
Lara R. S. Fonseca, Gonçalo R. Silva, Ângelo Luís, Henrique J. Cardoso, Sara Correia, Cátia V. Vaz, Ana P. Duarte, Sílvia Socorro
Molecules. 2021; 26(10): 2941
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369 New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene
Boon-Peng Puah, Juriyati Jalil, Ali Attiq, Yusof Kamisah
Molecules. 2021; 26(13): 3888
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370 Targeting Inflammation by Anthocyanins as the Novel Therapeutic Potential for Chronic Diseases: An Update
Aleksandra Kozlowska, Tomasz Dzierzanowski
Molecules. 2021; 26(14): 4380
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371 New Series of Pyrazoles and Imidazo-Pyrazoles Targeting Different Cancer and Inflammation Pathways
Maria Grazia Signorello, Federica Rapetti, Elda Meta, Adama Sidibè, Olga Bruno, Chiara Brullo
Molecules. 2021; 26(19): 5735
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372 Anti-Gastritis and Anti-Lung Injury Effects of Pine Tree Ethanol Extract Targeting Both NF-?B and AP-1 Pathways
Seung A Kim, Jieun Oh, Se Rin Choi, Choong Hwan Lee, Byoung-Hee Lee, Mi-Nam Lee, Mohammad Amjad Hossain, Jong-Hoon Kim, Sarah Lee, Jae Youl Cho
Molecules. 2021; 26(20): 6275
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373 The Impact of Immune Checkpoint-Inhibitors Therapy in Urinary Bladder Cancer
Ana Lúcia Silva, Pedro Abreu-Mendes, Diana Martins, Fernando Mendes
Onco. 2021; 1(1): 3
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374 Impact of Sexual Activity on the Risk of Male Genital Tumors: A Systematic Review of the Literature
Felice Crocetto, Davide Arcaniolo, Luigi Napolitano, Biagio Barone, Roberto La Rocca, Marco Capece, Vincenzo Francesco Caputo, Ciro Imbimbo, Marco De Sio, Francesco Paolo Calace, Celeste Manfredi
International Journal of Environmental Research and Public Health. 2021; 18(16): 8500
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375 Immunomodulatory Activity of Phyllanthus maderaspatensis in LPS-Stimulated Mouse Macrophage RAW 264.7 Cells
Uoorakkottil Ilyas, Deepshikha P. Katare, Punnoth Poonkuzhi Naseef, Mohamed Saheer Kuruniyan, Muhammed Elayadeth-Meethal, Vidhu Aeri
Separations. 2021; 8(9): 129
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376 Nanocarriers as a Tool for the Treatment of Colorectal Cancer
Ana Luiza C. de S. L. Oliveira, Timo Schomann, Lioe-Fee de Geus-Oei, Ellen Kapiteijn, Luis J. Cruz, Raimundo Fernandes de Araújo Junior
Pharmaceutics. 2021; 13(8): 1321
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377 Exosomes as a New Delivery Vehicle in Inflammatory Bowel Disease
Xiaomei Wang, Guoliang Zhou, Wanwan Zhou, Xin Wang, Xiao Wang, Chenggui Miao
Pharmaceutics. 2021; 13(10): 1644
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378 Evaluation of Anti-Cancer Activity of Gryllus bimaculatus Water Extract on Non-Small Cancer Lung Cell via Apoptosis
Hyun Jung Lim, Eui-Hong Byun
Preventive Nutrition and Food Science. 2021; 26(4): 453
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379 Mediators of extracellular matrix degradation and inflammation: A new team of possible biomarkers for oral squamous cell carcinoma stage
Radu Radulescu, Alexandra Totan, Marina Imre, Daniela Miricescu, Andreea Didilescu, Maria Greabu
Experimental and Therapeutic Medicine. 2021; 22(2)
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380 In vitro assessment of the cytotoxicity and anti-inflammatory properties of a novel dietary supplement
Ionela Popescu, Elena Codrici, Simona Mihai, Cristina-Mihaela Luntraru, Mihaela Neagu, Cristiana Tanase
Experimental and Therapeutic Medicine. 2021; 22(4)
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381 Opioids in cancer: The ?-opioid receptor (Review)
Qier Zhou, Zhiwei Zhang, Songkai Long, Wanjun Li, Baiyun Wang, Na Liang
Molecular Medicine Reports. 2021; 25(2)
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382 Hyperinsulinemia in Obesity, Inflammation, and Cancer
Anni M.Y. Zhang, Elizabeth A. Wellberg, Janel L. Kopp, James D. Johnson
Diabetes & Metabolism Journal. 2021; 45(3): 285
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383 Persistent Small Bowel Obstruction due to Small Bowel Adenocarcinoma: A Case Report
Orlando Fleites, Stephanie S Pelenyi, Charles K Lee, Christopher A Wisnik, Ammarah Tariq, Ameen Abdel-Khalek, Frederick M Tiesenga
Cureus. 2021;
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384 Epidemiology of Bladder Cancer
Kalyan Saginala, Adam Barsouk, John Sukumar Aluru, Prashanth Rawla, Sandeep Anand Padala, Alexander Barsouk
Medical Sciences. 2020; 8(1): 15
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385 Epidemiology, Staging and Management of Prostate Cancer
Adam Barsouk, Sandeep Anand Padala, Anusha Vakiti, Azeem Mohammed, Kalyan Saginala, Krishna Chaitanya Thandra, Prashanth Rawla, Alexander Barsouk
Medical Sciences. 2020; 8(3): 28
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386 Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism
Rafael Agustín Burgos, Pablo Alarcón, John Quiroga, Carolina Manosalva, Juan Hancke
Molecules. 2020; 26(1): 5
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387 The Adenosine System at the Crossroads of Intestinal Inflammation and Neoplasia
Vanessa D’Antongiovanni, Matteo Fornai, Carolina Pellegrini, Laura Benvenuti, Corrado Blandizzi, Luca Antonioli
International Journal of Molecular Sciences. 2020; 21(14): 5089
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388 Targeting of CD163+ Macrophages in Inflammatory and Malignant Diseases
Maria K. Skytthe, Jonas Heilskov Graversen, Søren K. Moestrup
International Journal of Molecular Sciences. 2020; 21(15): 5497
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389 Chemopreventive Effect of Dietary Anthocyanins against Gastrointestinal Cancers: A Review of Recent Advances and Perspectives
K.V. Surangi Dharmawansa, David W. Hoskin, H. P. Vasantha Rupasinghe
International Journal of Molecular Sciences. 2020; 21(18): 6555
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390 Fucoxanthin, a Marine-Derived Carotenoid from Brown Seaweeds and Microalgae: A Promising Bioactive Compound for Cancer Therapy
Sarah Méresse, Mostefa Fodil, Fabrice Fleury, Benoît Chénais
International Journal of Molecular Sciences. 2020; 21(23): 9273
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391 The Gut Microbiota and Inflammation: An Overview
Zahraa Al Bander, Marloes Dekker Nitert, Aya Mousa, Negar Naderpoor
International Journal of Environmental Research and Public Health. 2020; 17(20): 7618
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392 Comorbidity in Older Patients Hospitalized with Cancer in Northeast China based on Hospital Discharge Data
Xiao-Min Mu, Wei Wang, Fang-Yi Wu, Yu-Ying Jiang, Ling-ling Ma, Jia Feng
International Journal of Environmental Research and Public Health. 2020; 17(21): 8028
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393 Dietary Flavonoids in p53—Mediated Immune Dysfunctions Linking to Cancer Prevention
Shoib Sarwar Siddiqui, Sofia Rahman, H.P. Vasantha Rupasinghe, Cijo George Vazhappilly
Biomedicines. 2020; 8(8): 286
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394 Natural Compounds with Potential to Modulate Cancer Therapies and Self-Reactive Immune Cells
Rhiane Moody, Kirsty Wilson, Anthony Jaworowski, Magdalena Plebanski
Cancers. 2020; 12(3): 673
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395 Proteoglycans in the Pathogenesis of Hormone-Dependent Cancers: Mediators and Effectors
George Tzanakakis, Eirini-Maria Giatagana, Andrey Kuskov, Aikaterini Berdiaki, Aristidis Tsatsakis, Monica Neagu, Dragana Nikitovic
Cancers. 2020; 12(9): 2401
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396 Lactobacillus Attenuate the Progression of Pancreatic Cancer Promoted by Porphyromonas Gingivalis in K-rasG12D Transgenic Mice
Shan-Ming Chen, Li-Jin Hsu, Hsiang-Lin Lee, Ching-Pin Lin, Szu-Wei Huang, Caucasus Jun-Lin Lai, Chia-Wei Lin, Wan-Ting Chen, Yu-Jen Chen, Yu-Chien Lin, Chi-Chieh Yang, Ming-Shiou Jan
Cancers. 2020; 12(12): 3522
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397 The Role of CDK5 in Tumours and Tumour Microenvironments
Phuong Anh Do, Chang Hoon Lee
Cancers. 2020; 13(1): 101
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398 Health Impacts of a Traditional Illicit Brew (Kaanga) Consumed in Meru County, Kenya
Atuna Titus Gitari, Osano Aloys, Bakari Chaka, Bulitia Godrick
European Journal of Environment and Public Health. 2020; 5(1): em0065
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399 Investigation of the neutrophil/lymphocyte and monocyte to high-density lipoprotein cholesterol ratios in differentiated thyroid cancers
Kenan ÇADIRCI, Faruk YILDIZ, Havva KESKIN, Muharrem BAYRAK, Hilal KIZILTUNC OZMEN, Senay ARIKAN DURMAZ, Ayse ÇARLIOGLU
Journal of Health Sciences and Medicine. 2020;
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400 Cytokines/Chemokines: Potential Biomarkers for Non-paraneoplastic Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Jingwen Liu, Lei Liu, Wenting Kang, Gongxin Peng, Di Yu, Qiuying Ma, Yatong Li, Yan Zhao, Lin Li, Feifei Dai, Jiawei Wang
Frontiers in Neurology. 2020; 11
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401 Mini Review: Opposing Pathologies in Cancer and Alzheimer's Disease: Does the PI3K/Akt Pathway Provide Clues?
Rachel M. Barker, Jeff M. P. Holly, Kalina M. Biernacka, Shelley J. Allen-Birt, Claire M. Perks
Frontiers in Endocrinology. 2020; 11
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402 Germacrone: A Potent Secondary Metabolite with Therapeutic Potential in Metabolic Diseases, Cancer and Viral Infections
Ammara Riaz, Azhar Rasul, Nazia Kanwal, Ghulam Hussain, Muhammad Ajmal Shah, Iqra Sarfraz, Rubab Ishfaq, Rabia Batool, Fariha Rukhsar, Sevki Adem
Current Drug Metabolism. 2020; 21(14): 1079
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403

Dynamic Changes in the Neutrophil-to-Lymphocyte Ratio Predict the Prognosis of Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization
Hongyu Wang, Chuyang Lin, Wenzhe Fan, Jiang Zhang, Yingqiang Zhang, Wang Yao, Jiaping Li
Cancer Management and Research. 2020; Volume 12: 3433
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404 Nano drug delivery systems in upper gastrointestinal cancer therapy
Julia Salapa, Allison Bushman, Kevin Lowe, Joseph Irudayaraj
Nano Convergence. 2020; 7(1)
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405 Inflammation and Inflammasomes: Pros and Cons in Tumorigenesis
Liliana R. Balahura, Aida Selaru, Sorina Dinescu, Marieta Costache
Journal of Immunology Research. 2020; 2020: 1
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406 Interleukin-1ß und pro-tumorale Inflammation – Zentrale Faktoren bei der Entstehung von Krebserkrankungen
Sebastian Kobold, Martin Reck
Oncology Research and Treatment. 2020; 43(3): 6
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407 Association of interleukin-6 gene polymorphisms with the risk of hepatocellular carcinoma
Pei-Pei An, Li-Na Feng, Xiao-Xue Zhang, Qing-Long Jin
Medicine. 2020; 99(50): e23659
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408 Potent anti-inflammatory Terminalia chebula fruit showed in vitro anticancer activity on lung and breast carcinoma cells through the regulation of Bax/Bcl-2 and caspase-cascade pathways
Anil Khushalrao Shendge, Rhitajit Sarkar, Nripendranath Mandal
Journal of Food Biochemistry. 2020; 44(12)
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409 Carotenoid isolates of Spondias mombin demonstrate anticancer effects in DMBA-induced breast cancer in Wistar rats through X-linked inhibitor of apoptosis protein (XIAP) antagonism and anti-inflammation
Damilohun Samuel Metibemu, Oluseyi Adeboye Akinloye, Adio Jamiu Akamo, Jude Ogechukwu Okoye, David Ajiboye Ojo, Eric Morifi, Idowu Olaposi Omotuyi
Journal of Food Biochemistry. 2020; 44(12)
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410 3a-Angeloyloxy-ent-kaur-16-en-19-oic Acid Isolated from Wedelia trilobata L. Alleviates Xylene-Induced Mouse Ear Edema and Inhibits NF-?B and MAPK Pathway in LPS-Stimulated Macrophages
Jingwen Xu, Lei Zhou, Lianlian Sun, Zhe Wang, Yi Wang, Yihai Wang, Xiangjiu He
Journal of Natural Products. 2020; 83(12): 3726
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411 Correlation of D-xylose with severity and morbidity-related factors of COVID-19 and possible therapeutic use of D-xylose and antibiotics for COVID-19
Antony Cheudjeu
Life Sciences. 2020; 260: 118335
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412 Modern menstruation: Is it abnormal and unhealthy?
Norman D. Goldstuck
Medical Hypotheses. 2020; 144: 109955
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413 Is the presence of lung injury in COVID-19 an independent risk factor for secondary lung cancer?
Shao-Lin Tao, Xue-mei Wang, Yong-geng Feng, Po-ming Kang, Qing-yuan Li, Tian-yu Sun, Qun-you Tan, Bo Deng
Medical Hypotheses. 2020; 143: 110074
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414 Association between dietary inflammatory index and upper aerodigestive tract cancer risk: A systematic review and dose-response meta-analysis
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Oral Oncology. 2020; 103: 104587
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415 Mechanisms of NLRP3 priming in inflammaging and age related diseases
Anna Gritsenko, Jack P. Green, David Brough, Gloria Lopez-Castejon
Cytokine & Growth Factor Reviews. 2020; 55: 15
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416 An evaluation on potential anti-inflammatory effects of ß-lapachone
Narmin Mokarizadeh, Pouran Karimi, Hamid Kazemzadeh, Nazila Fathi Maroufi, Saeed Sadigh-Eteghad, Saba Nikanfar, Nadereh Rashtchizadeh
International Immunopharmacology. 2020; 87: 106810
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417 Oleandrin: A bioactive phytochemical and potential cancer killer via multiple cellular signaling pathways
Nazia Kanwal, Azhar Rasul, Ghulam Hussain, Haseeb Anwar, Muhammad Ajmal Shah, Iqra Sarfraz, Ammara Riaz, Rabia Batool, Muhammad Shahbaz, Arif Hussain, Zeliha Selamoglu
Food and Chemical Toxicology. 2020; 143: 111570
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418 Secreted protein acidic and rich in cysteine and inflammation: Another homeostatic property?
Abdelaziz Ghanemi, Mayumi Yoshioka, Jonny St-Amand
Cytokine. 2020; 133: 155179
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419 Resistin: An inflammatory cytokine with multi-faceted roles in cancer
Sarabjeet Kour Sudan, Sachin Kumar Deshmukh, Teja Poosarla, Nicolette Paolaungthong Holliday, Donna Lynn Dyess, Ajay Pratap Singh, Seema Singh
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 2020; 1874(2): 188419
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420 The P2X7 purinergic receptor: a potential therapeutic target for lung cancer
Qianqian Li, Xiaodi Zhu, Wei Song, Xiaoxiang Peng, Ronglan Zhao
Journal of Cancer Research and Clinical Oncology. 2020; 146(11): 2731
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421 Ethyl Acetate Fraction of Adenophora triphylla var. japonica Inhibits Migration of Lewis Lung Carcinoma Cells by Suppressing Macrophage Polarization toward an M2 Phenotype
Shin-Hyung Park
Journal of Pharmacopuncture. 2019; 22(4): 253
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