Annals of African Medicine
Home About AAM Editorial board Ahead of print Current Issue Archives Instructions Subscribe Contact us Search Login 


 
Table of Contents
ORIGINAL ARTICLE
Year : 2016  |  Volume : 15  |  Issue : 2  |  Page : 63-68  

Pattern and outcome of renal admissions at the University of Port Harcourt Teaching Hospital, Nigeria: A 4 years review


Department of Medicine, Faculty of Clinical Sciences, College of Health Sciences, University of Port Harcourt; Department of Internal Medicine, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria

Date of Web Publication5-Apr-2016

Correspondence Address:
Chinyere Mmanwanyi Wachukwu
Department of Medicine, Faculty of Clinical Sciences, College of Health Sciences, University of Port Harcourt, Port Harcourt
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1596-3519.172559

Rights and Permissions
   Abstract 

Background/Objective: Renal diseases constitute an enormous health burden globally, more so in developing countries. This report determines the patterns and outcomes of renal diseases in the medical wards of the University Teaching Hospital in Nigeria.
Methods: A retrospective study of patients admitted for renal disease in 4 years.
Results: A total of 3841 patients were admitted to the medical wards, of which 590 (15.4%) had renal disease. Mean age of patients was 46 ± 15 years. Median duration of admission was 14 days (range 1–92 days). The most prevalent renal diseases were hypertensive nephropathy, diabetic nephropathy, chronic glomerulonephritis, and HIV-related renal disease constituting 22.8%, 16.6%, 14.4%, and 13.1%, respectively. Acute kidney injury constituted 12.4% of renal admissions. Analysis of outcome showed that 317 (53.7%) were discharged home, 49 (8.3%) patients discharged themselves against medical advice or absconded while 120 (20.3%) patients died of the disease. The highest mortality rate (22.5%) was observed among patients with the HIV-related renal disease.
Conclusion: Renal disease remains a significant cause of morbidity and mortality in Port Harcourt, Southern Nigeria. This underscores an urgent need to institute measures for prevention and early detection of renal disease and reduction of its burden.

   Abstract in French 

Résumé
Contexte/objectif: Maladies rénales constituent un fardeau énorme dans le monde, autant dans les pays en développement. Ce rapport détermine les modéles et les résultats des maladies rénales dans les services médicaux de l'hôpital universitaire de l'Université au Nigeria.
Méthodes: Une étude rétrospective des patients admis pour une maladie rénale en 4 ans.
Résultats: 3841 patients au total ont été admis dans les services médicaux, dont 590 (15,4 %) avaient une maladie rénale. L'àâge moyen des patients était de 46 ± 15 ans. La durée médiane d'admission était de 14 jours (extrêmes 1 – 92 jours). Les maladies rénales les plus fréquentes étaient la néphropathie hypertensive, néphropathie diabétique, glomérulonéphrite chronique et maladie rénale liée au VIH, constituant de 22,8 %, 16,6 %, 14,4 % et 13,1 %, respectivement. Insuffisance rénale aiguë constitue 12,4 % des admissions rénales. Analyse des résultats a montré que 317 (53,7 %) sont sortis de la maison, 49 (8,3 %) patients eux-mêmes rejetés contre avis médical ou ont pris la fuite alors que 120 patients (20,3 %) sont décédés de la maladie. Le taux de mortalité plus élevé (22,5 %) a été observé chez les patients présentant la maladie rénale liée au VIH.
Conclusion: Maladie rénale reste une cause importante de morbidité et de mortalité à Port Harcourt, Nigeria du Sud. Cela met en évidence un besoin urgent d'instituer des mesures de prévention et de détection précoce de la maladie rénale et de la réduction du fardeau qui lui incombait.
Mots-clés: Résultats, les modèles, les admissions de néphropathie

Keywords: Outcomes, patterns, renal disease admissions


How to cite this article:
Wachukwu CM, Emem-Chioma PC, Wokoma FS, Oko-Jaja RI. Pattern and outcome of renal admissions at the University of Port Harcourt Teaching Hospital, Nigeria: A 4 years review. Ann Afr Med 2016;15:63-8

How to cite this URL:
Wachukwu CM, Emem-Chioma PC, Wokoma FS, Oko-Jaja RI. Pattern and outcome of renal admissions at the University of Port Harcourt Teaching Hospital, Nigeria: A 4 years review. Ann Afr Med [serial online] 2016 [cited 2021 Nov 27];15:63-8. Available from: https://www.annalsafrmed.org/text.asp?2016/15/2/63/172559


   Introduction Top


The pattern of medical admissions in different regions of the world varies, and in developing countries such as in Nigeria, a trend toward noncommunicable diseases (NCDs) has been documented to account for a significant percentage of medical admissions.[1],[2] This is in line with the prediction by the World Health Organization, which suggests that by 2030, the causes of disease and death in Sub-Saharan Africa (SSA) will have undergone a shift away from communicable and infectious diseases to NCDs.[3]

Kidney disease, particularly chronic kidney disease (CKD) plays a key role in determining health outcomes among the major NCDs, particularly diabetes and cardiovascular disease [4] and thus, has become a major public health concern worldwide rising as an NCD burden,[5] further adding to the burden of chronic medical disorders in hospitals.

In the Unites States, 10% of adults amounting to >20 million people are reported to have CKD with diabetes mellitus and hypertension being the leading causes of end-stage renal disease (ESRD).[6] In Nigeria and most Sub-Saharan African countries, population-based data of CKD are not common. Most of the data are hospital based. Earlier studies in Nigeria reported that CKD accounted for 8–10% of hospital admissions,[7] and in a Tertiary Hospital in South-East Nigeria, ESRD accounted for 7.96% of all medical admissions and 41.69% of renal admissions.[8]

In SSA, hypertension and glomerular diseases are common causes of CKD with an increasing prevalence of diabetic nephropathy as a cause of ESRD ranging from 6% to 16%.[9] A similar pattern has been observed in Nigeria where chronic glomerulonephritis (CGN), hypertension, and diabetes are the most common causes of CKD.[7],[8],[10] Communicable diseases, particularly HIV infection is also thought to contribute to the burden of CKD in SSA.[5] The etiology of renal disease in HIV-infected persons is multi-factorial and includes the direct effect of the virus, presence of co-morbidities, and side effects of anti-retroviral drugs.[11]

Acute kidney injury (AKI), predominantly community-acquired type, is also an increasing cause of hospitalization with a high morbidity and mortality in this environment.[12],[13],[14]

The aim of this study was to determine the pattern and outcome of renal diseases in patients admitted to the medical wards of the University of Port Harcourt Teaching hospital (UPTH), Nigeria, over a 4 years period (January 2010–December 2013).


   Methods Top


This was a retrospective study conducted at the UPTH from data generated between January 2010 and December 2013. The UPTH is one of the major tertiary institutions in the oil-rich Niger Delta Region of Nigeria and serves as a referral center for Rivers state and neighboring Niger Delta regional states of Nigeria as well as some neighboring South-Eastern states. Patients are admitted to the medical wards via the Accident and Emergency Department, the medical out-patient clinics and the renal clinic.

Admission and discharge records were retrieved from the medical register in the medical wards. Information retrieved included age, sex, clinical diagnosis, date of admission, duration of hospital stay, and outcomes of treatment. The clinical outcome variables were discharged following improvement, absconded or discharged against medical advice, referral to another health facility and death.

Approval for the study was obtained from the Hospitals Research Ethics Committee.

Statistics

Collated data were analyzed using Statistical Package for Social Sciences version 17 (SPSS version 17, Chicago: SPSS Inc). Continuous variables were expressed as median or mean ± standard deviation while categorical variables were expressed as frequencies and percentages. The Student's t-test was used to compare continuous variables. Nonparametric tests as appropriate were used for data not normally distributed. A P < 0.05 was considered statistically significant.


   Results Top


During the study period of 4 years (January 2010–December 2013), a total of 3841 patients were admitted to the medical wards of the hospital. Males constituted 2004 (52.2%), and females were 1837 (47.8%). The annual gender distribution of patients is shown in [Figure 1].
Figure 1: Annual gender distribution of total medical admissions over the 4 years review period

Click here to view


Renal diseases accounted for 590 (15.4%) of total medical admissions in the ward. The annual renal admission trend is shown in [Figure 2].
Figure 2: Annual renal admissions trend from January 2010 to December 2013

Click here to view


The mean age of patients with renal disease was 46 ± 15 years with a range of 17–85 years. The male patients were older, but this was not significant (47 ± 15 vs. 44 ± 16 years, P = 0.05). [Figure 3] shows the age distribution of the patients with the peak group in the 30–39 years age group constituting 23%. The bulk of the patients were in the 30–39, 40–49, and 50–59 years age groups, respectively, constituting 60.2% of all patients.
Figure 3: Age distribution of renal patients

Click here to view


The median duration of admission for renal patients was 14 days (range 1–92 days). No significant statistical difference was observed in the median duration of admission between males (14 days, range 1–92 days) and females (14 days, range 1–77 days); P = 0.332.

The distribution of the patients in accordance with the underlying renal disease is shown in [Figure 4]. The five leading causes were hypertensive nephropathy in 134 (22.8%), diabetic nephropathy in 98 (16.6%), CGN in 85 (14.4%), HIV-related renal disease in 77 (13.1%), and AKI in 73 (12.4%) patients, respectively.
Figure 4: Pattern of renal diseases during the 4 years review period

Click here to view


Over this review period, 120 deaths were recorded, corresponding to 20.3% mortality rate, 76 (63.3%) of the demised were males and 44 (36.7%) females (P = 0.001). A total of 317 (53.3%) of patients were discharged following clinical improvement, and 49 (8.3%) discharged themselves against medical advice or absconded [Figure 5]. No outcome was indicated in ward records for 103 (17.5%) patients.
Figure 5: Outcome of renal admissions

Click here to view


The highest mortality, 22.5%, was seen in patients with the HIV-related renal disease while patients presenting with nephrotic syndrome accounted for 4.2% of mortality. Patients with renal disease of unknown etiology had a mortality of 15% [Figure 6]. Logistic regression showed a significant negative relationship between the duration of hospital stay and mortality, with a shorter admission duration being associated with increased mortality (B = −0.029, P = 0.005).
Figure 6: Pattern of outcome of mortality based on clinical diagnosis among patients

Click here to view



   Discussion Top


This study aimed to determine the patterns of renal disease in patients admitted to the medical wards of UPTH over a 4 years period.

The peak age prevalence of patients admitted over this period was between the fourth and sixth decades, similar to previous studies in Nigeria.[15],[16] These are patients in the economically active age group, and this could be telling on the nation's economy. In contrast, in the United States, the Third National Health and Nutrition Examination Survey reports that CKD is more prevalent in adults over 60 years (39.4%) than in those aged 40–59 years (12.6%) and 20–39 years (8.5%).[17]

This study documented that renal diseases accounted for 15.4% of all medical admissions over the 4 years review period. In tropical countries, it is estimated that 2–3% of medical admissions are due to renal-related complaints.[18] Agomuoh and Unachukwu,[1] in an earlier study in Port Harcourt, reported that renal disease accounted for 16.8% of medical admissions. In South-West Nigeria, a lower prevalence rate of 6.5% of medical cases over a 3 years period were also due to renal disease in Oshogbo [19] while, in Ekiti State, Ogunmola and Oladosu [2] reported a prevalence of 7.2% over 2 years. The total number of medical admissions in this study was observed to gradually reduce in the last 2 years in review, though the percentage of renal cases remained between 11.6% and 18.2%. This high prevalence underscores the measure of the burden CKD places on the health care system in Nigeria. The median duration of hospital stay observed among the patients was 17 days with a range of 1–92 days. The majority of patients in Nigeria are self-funded or are funded by relatives, and prolonged hospital stay puts increased financial strain on families, in an economy that is already fraught with poverty and austerity.

The most common causes of renal diseases admitted were hypertensive nephropathy, diabetic nephropathy, and CGN. In Nigeria, studies report CGN leading as the most common cause of CKD followed by hypertension and diabetes.[7],[20] This study reports hypertension and diabetes ranking above CGN with the possibility that the prevalence of CGN may be higher owing to the fact that up to 13.4% of the patients had CKD from unidentified causes. Other recent studies in Nigeria have shown hypertension overtaking CGN as a cause of CKD similar to this study.[8],[21] Hypertension in blacks is said to occur earlier with its consequences of target organ damage including renal disease being more pronounced.[22],[23] Hypertension is also reported to be the leading cause of CKD in SSA.[9] In a rural South Africa community, hypertension accounted for 77.8% of patients with renal disease,[24] and in North Africa, reports from nephrologists puts the prevalence of hypertensive nephrosclerosis at 10–35%.[25] In contrast to this preeminence of hypertension as a cause of renal disease in Africa, diabetes mellitus is identified across other regions of the world as the leading cause of CKD and ESRD.[26] With Nigeria reported to have the largest number of people in Africa living with type 2 diabetes [27] and type 2 diabetes increasingly becoming a leading cause of CKD and ESRD in Nigeria,[28] we may be observing the earliest trends of an emerging CKD epidemic in this local setting despite the inherent shortcomings of being a retrospective and single-hospital study.

In this study, AKI accounted for 12.4% of admissions with a mortality of 12.5%. A meta-analysis of worldwide incidence of AKI reported an incidence rate of 21.6% in adults and a mortality rate of 23.9% with the highest rates observed in critical care settings.[29] AKI is also known to be associated with high morbidity and mortality despite enormous improvements in knowledge, skills, and available technology; this is particularly so in developing countries with resource-poor settings, such as shown by several studies in Nigeria.[12],[13],[14]

This study showed a 13.1% prevalence of renal disease in HIV-infected patients. Nephropathy is common in HIV-infected patients, and Emem et al.[30] reported a high prevalence (38%) of renal disease in HIV patients in Nigeria. The highest mortality in this study was seen in patients with HIV infection. Kidney disease remains a significant cause of morbidity and mortality in this group of patients even in those receiving antiretroviral drugs, and the reasons for this high mortality are multi-factorial. It may be due to the fact that HIV-associated nephropathy is thought to follow a more severe course in blacks with rapid progression to ESRD.[31] AKI is also prevalent in patients with HIV infection, increasing the mortality in them. In this subgroup, the clinical outcome may be compounded by the presence of multiple co-morbidities as well as the side effects of anti-retroviral drugs.[11] Studies among medical admissions in Nigeria have also reported high mortality rates in patients with HIV infection.[32],[33]

The overall mortality rate of 20.3% was high in this study, and 8.3% of patients discharged themselves against medical advice or absconded from the hospital. Studies have identified reasons that patients may choose to go home against medical advice, and these include financial constraints, unsatisfactory clinical improvement, the desire to seek alternative or complimentary treatment, poor communication between patients and health care providers among others reasons.[34],[35] Logistic regression analysis in this study showed a that a shorter duration of admission was related to mortality, and this may suggest late presentations to the hospital in this group of patients with likely advanced stages of illness and hence a worse outcome. The clinical outcome in 17.5% of patients was not indicated in records underscoring the need for adequate record keeping in this environment.

This study is not without its limitations. Records in the hospital are kept manually; as a result, some books were torn and mutilated with resultant lack of some vital information in the records. Furthermore, changes which may have been made in patient diagnosis following further laboratory investigations may not be reflected in final diagnosis.


   Conclusion Top


Renal disease is highly prevalent and accounts for a significant proportion of medical admissions in Port Harcourt, Nigeria. Hypertension, diabetes, and CGN remain the most common causes of CKD with diabetic renal disease gaining ground over CGN and with HIV becoming a significant cause of renal disease. The mortality in renal disease is high and more so in patients with HIV infection. Health education must be reinforced through various media with emphasis on lifestyle modification in addition to population screening exercises to detect major cardiovascular risk factors such as diabetes and hypertension and thus prevent and reduce the burden of kidney disease in Nigeria.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
   References Top

1.
Agomuoh DI, Unachukwu CN. Pattern of diseases among medical admissions in Port Harcourt, Nigeria. Niger Med Pract 2007;51:45-50.  Back to cited text no. 1
    
2.
Ogunmola OJ, Oladosu OY. Pattern and outcome of admissions in the medical wards of a tertiary health center in a rural community of Ekiti State, Nigeria. Ann Afr Med 2014;13:195-203.  Back to cited text no. 2
[PUBMED]  Medknow Journal  
3.
WHO Global Status Report on Noncommunicable Diseases: Executive Summary. Available from: . [Last accessed on 2015 May 28].  Back to cited text no. 3
    
4.
Couser WG, Remuzzi G, Mendis S, Tonelli M. The contribution of chronic kidney disease to the global burden of major noncommunicable diseases. Kidney Int 2011;80:1258-70.  Back to cited text no. 4
    
5.
Stanifer JW, Jing B, Tolan S, Helmke N, Mukerjee R, Naicker S, et al. The epidemiology of chronic kidney disease in sub-Saharan Africa: A systematic review and meta-analysis. Lancet Glob Health 2014;2:e174-81.  Back to cited text no. 5
    
6.
National Chronic Kidney Disease Fact Sheet; 2014. Available from: . [Last accessed on 2014 May 04].  Back to cited text no. 6
    
7.
Akinsola W, Odesanmi WO, Ogunniyi JO, Ladipo GO. Diseases causing chronic renal failure in Nigerians – A prospective study of 100 cases. Afr J Med Med Sci 1989;18:131-7.  Back to cited text no. 7
    
8.
Ulasi II, Ijoma CK. The enormity of chronic kidney disease in Nigeria: The situation in a teaching hospital in South-East Nigeria. J Trop Med 2010;2010:501957.  Back to cited text no. 8
    
9.
Naicker S. End-stage renal disease in Sub-Saharan Africa. Kidney Int Suppl 2013;3:161-3.  Back to cited text no. 9
    
10.
Akinsola A, Sanusi AA, Adekunle TA, Arogundade FA. Magnitude of the problem of chronic renal failure in Nigerians. Afr J Nephrol 2004;8:24-6.  Back to cited text no. 10
    
11.
Röling J, Schmid H, Fischereder M, Draenert R, Goebel FD. HIV-associated renal diseases and highly active antiretroviral therapy-induced nephropathy. Clin Infect Dis 2006;42:1488-95.  Back to cited text no. 11
    
12.
Effa EE, Okpa HO, Epoke EJ, Otokpa DE. Acute kidney injury in hospitalized patients at the University of Calabar Teaching Hospital: An aetiological and outcome study. IOSR J Dent Med Sci 2015;14:55-9.  Back to cited text no. 12
    
13.
Emem-Chioma PC, Alasia DD, Wokoma FS. Clinical outcomes of dialysis-treated acute kidney injury patients at the University of Port Harcourt teaching Hospital, Nigeria. ISRN Nephrol 2012;2013:540526.  Back to cited text no. 13
    
14.
Okunola OO, Ayodele OE, Adekanle AD. Acute kidney injury requiring hemodialysis in the tropics. Saudi J Kidney Dis Transpl 2012;23:1315-9.  Back to cited text no. 14
[PUBMED]  Medknow Journal  
15.
Afolabi MO, Abioye-Kuteyi EA, Arogundade FA. Prevalence of chronic kidney disease in a Nigerian family practice population. S Afr Fam Pract 2009;51:132-7.  Back to cited text no. 15
    
16.
Alebiosu CO, Ayodele OO, Abbas A, Olutoyin AI. Chronic renal failure at the Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria. Afr Health Sci 2006;6:132-8.  Back to cited text no. 16
    
17.
Centers for Disease Control and Prevention (CDC). Prevalence of chronic kidney disease and associated risk factors – United States, 1999-2004. MMWR Morb Mortal Wkly Rep 2007;56:161-5.  Back to cited text no. 17
    
18.
Etyang AO, Scott JA. Medical causes of admissions to hospital among adults in Africa: A systematic review. Glob Health Action 2013;6:1-14.  Back to cited text no. 18
    
19.
Okunola OO, Akintunde AA, Akinwusi PO. Some emerging issues in medical admission pattern in the tropics. Niger J Clin Pract 2012;15:51-4.  Back to cited text no. 19
[PUBMED]  Medknow Journal  
20.
Arogundade FA, Sanusi AA, Hassan MO, Akinsola A. The pattern, clinical characteristics and outcome of ESRD in Ile-Ife, Nigeria: Is there a change in trend? Afr Health Sci 2011;11:594-601.  Back to cited text no. 20
    
21.
Amira CO, Bello BT, Braimoh RW. Chronic kidney disease: A ten-year study of aetiology and epidemiological trends in Lagos, Nigeria. Br J Ren Med 2015;19:19-23.  Back to cited text no. 21
    
22.
Calhoun DA, Oparil S. Racial differences in the pathogenesis of hypertension. Am J Med Sci 1995;310 Suppl 1:S86-90.  Back to cited text no. 22
    
23.
Lackland DT, Keil JE. Epidemiology of hypertension in African Americans. Semin Nephrol 1996;16:63-70.  Back to cited text no. 23
    
24.
Malada ND, Thusi GP, Assounga AG, Naicker S. Characteristics of South African patients presenting with kidney disease in rural KwaZulu-Natal: A cross sectional study. BMC Nephrol 2014;15:16.  Back to cited text no. 24
    
25.
Barsoum RS. Burden of chronic kidney disease: North Africa. Kidney Int Suppl 2013;3:164-6.  Back to cited text no. 25
    
26.
Atkins RC. The epidemiology of chronic kidney disease. Kidney Int 2005;67:514-8.  Back to cited text no. 26
    
27.
International Working Group on the Diabetic Foot. Available from: . [Last accessed on 2015 Apr 03].  Back to cited text no. 27
    
28.
Alebiosu CO, Ayodele OE. The increasing prevalence of diabetic nephropathy as a cause of end stage renal disease in Nigeria. Trop Doct 2006;36:218-9.  Back to cited text no. 28
    
29.
Susantitaphong P, Cruz DN, Cerda J, Abulfaraj M, Alqahtani F, Koulouridis I, et al. World incidence of AKI: A meta-analysis. Clin J Am Soc Nephrol 2013;8:1482-93.  Back to cited text no. 29
    
30.
Emem CP, Arogundade F, Sanusi A, Adelusola K, Wokoma F, Akinsola A. Renal disease in HIV-seropositive patients in Nigeria: An assessment of prevalence, clinical features and risk factors. Nephrol Dial Transplant 2008;23:741-6.  Back to cited text no. 30
    
31.
Laradi A, Mallet A, Beaufils H, Allouache M, Martinez F. HIV-associated nephropathy: Outcome and prognosis factors. Groupe d' Etudes Néphrologiques d'Ile de France. J Am Soc Nephrol 1998;9:2327-35.  Back to cited text no. 31
    
32.
Chijioke A, Kolo P. Mortality pattern at the adult medical wards of a teaching hospital in Sub-Saharan Africa. Int J Trop Med 2009;4:27-31.  Back to cited text no. 32
    
33.
Agomuoh D, Unachukwu C. The pattern and distribution of communicable diseases among medical admissions in Port Harcourt, Nigeria. Port Harcourt Med J 2007;1:52-5.  Back to cited text no. 33
    
34.
Fadare JO, Babatunde OA, Olanrewaju T, Busari O. Discharge against medical advice: Experience from a rural Nigerian Hospital. Ann Niger Med 2013;7:60-5.  Back to cited text no. 34
    
35.
Eze B, Agu K, Nwosu J. Discharge against medical advice at a tertiary centre in South-Eastern Nigeria: Sociodemographic and clinical dimensions. Patient Intell 2010;2:27-31.  Back to cited text no. 35
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6]



 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    Abstract
   Introduction
   Methods
   Results
   Discussion
   Conclusion
    References
    Article Figures

 Article Access Statistics
    Viewed4587    
    Printed91    
    Emailed2    
    PDF Downloaded28    
    Comments [Add]    

Recommend this journal