Annals of African Medicine
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Year : 2007  |  Volume : 6  |  Issue : 4  |  Page : 207-208

Hyponatraemia during low-dose carbamazepine therapy

1 Department of Medicine, State Specialist Hospital, Maiduguri 600001, Nigeria
2 Department of Medicine, Federal Medical Centre, Yola 640001, Nigeria

Correspondence Address:
F Salawu
P. O. Box 246, Maiduguri 600001
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1596-3519.55693

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We report the syndrome of inappropriate antidiuresis as a much earlier side-effect of carbamazepine administration in a 29-year Nigerian female patient with generalized tonic-clonic seizures. Although asymptomatic, the biochemical abnormality improved after discontinuation of carbamazepine. Hyponatraemia developed after rechallenge with controlled release carbamazepine. The authors suggest that serum sodium levels be carried out before commencement of carbamazepine and caution be used in prescribing carbamazepine to patients with low or borderline low sodium values.

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