Annals of African Medicine

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 18  |  Issue : 2  |  Page : 103--107

Serum procalcitonin levels in chronic obstructive pulmonary disease patients in North Indian Population


Sarika Pandey1, Rajiv Garg1, Surya Kant1, Ajay Verma1, Priyanka Gaur2 
1 Department of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India
2 Department of Physiology, King George's Medical University, Lucknow, Uttar Pradesh, India

Correspondence Address:
Dr. Rajiv Garg
Department of Respiratory Medicine, King George's Medical University, Lucknow . 226 010, Uttar Pradesh
India

Background: Exacerbations in Chronic obstructive pulmonary disease (COPD) have a considerable impact on morbidity, mortality, and quality of life. Procalcitonin (PCT) a polypeptide normally produced in neuroendocrine cells of the thyroid and lungs is a marker of systemic inflammation and bacterial infection. Objectives: The aim of this study was to determine the levels of PCT in serum of acute exacerbation of COPD patients (AECOPD) and stable COPD patients in North Indian population. Materials and Methods: The study was conducted on 80 AECOPD and 80 stable COPD patients in respiratory medicine department at tertiary care hospital in north India. PCT levels were measured in serum by ELISA kit. GraphPad Prism version 6.01 (GraphPad software Inc.; La, Jolla, CA, USA) was used for analysis of data. Results: The present study showed that mean serum PCT levels were significantly higher in AECOPD group (1.31 ± 0.79) as compared to stable COPD group (0.1 ± 0.09) (P < 0.001). Conclusion: The study confirms that PCT levels were higher in AECOPD patients as compared to stable COPD patients. PCT could be used as a biomarker of exacerbations of COPD and can be used to target management and guiding the treatment in patients with acute exacerbations of COPD.


How to cite this article:
Pandey S, Garg R, Kant S, Verma A, Gaur P. Serum procalcitonin levels in chronic obstructive pulmonary disease patients in North Indian Population.Ann Afr Med 2019;18:103-107


How to cite this URL:
Pandey S, Garg R, Kant S, Verma A, Gaur P. Serum procalcitonin levels in chronic obstructive pulmonary disease patients in North Indian Population. Ann Afr Med [serial online] 2019 [cited 2019 Dec 8 ];18:103-107
Available from: http://www.annalsafrmed.org/article.asp?issn=1596-3519;year=2019;volume=18;issue=2;spage=103;epage=107;aulast=Pandey;type=0