Annals of African Medicine
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ORIGINAL ARTICLE
Year : 2019  |  Volume : 18  |  Issue : 2  |  Page : 92-96

Effect of scaling and root planing on gingival crevicular fluid levels of adrenomedullin in chronic periodontitis patients with and without diabetes mellitus type 2: A clinico-biochemical study


1 Department of Periodontics, Clove Dental Hospital, Hyderabad, Telangana, India
2 Department of Periodontics, Bapuji Dental College and Hospital, Davangere, Karnataka, India
3 Department of Oral Pathology, Celebrity Smiles Dental Clinic, Bangalore, Karnataka, India
4 Department of Periodontics, Dr. Hedgewar Smruti Rugna Seva Mandals Dental College and Hospital, Hingoli, Maharastra, India
5 Department of Periodontics, Dhanbad Nursing Home (P) Ltd, Amri Hospital, Kolkata, India
6 General Dentist, First Choice Community Health Center, Connecticut, United States of America

Correspondence Address:
Dr. Lavanya Pragada
Department of Periodontics, Clove Dental Clinic, Hyderabad, Telangana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aam.aam_40_18

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Background: Increased plasma adrenomedullin levels are usually observed in certain conditions such as diabetes mellitus (DM). Aims and Objectives: To gauge adrenomedullin values in the gingival crevicular fluid (GCF) of healthy individuals, chronic periodontitis (CP) patients with and without DM, and diabetics without any periodontal involvement, prior and after periodontal therapy. Materials and Methods: A total of 120 subjects were segregated into four categories of 30 each: Group 1 (healthy subjects), Group 2 (CP without DM), Group 3 (patients with CP and DM), and Group 4 (diabetics without any periodontal involvement). GCF was collected from all the patients. Nonsurgical periodontal therapy was done in Group 2 and Group 3 patients, followed up for 6 weeks, and GCF was obtained again from the same site. Enzyme-linked immunosorbent assay was used to evaluate the samples. Results: Adrenomedullin level in the GCF was high in diabetics without any periodontal involvement than in healthy individuals and significantly elevated in those with CP and DM. Reduced adrenomedullin was noted 6 weeks postperiodontal therapy. Conclusion: Adrenomedullin levels being higher in diabetics without any periodontal involvement than healthy controls suggest a link between DM and adrenomedullin. Furthermore, infection plays a noteworthy role in the elevation of adrenomedullin, indicating its role in periodontal disease progression.


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