|Year : 2019 | Volume
| Issue : 2 | Page : 86-91
Clinicopathologic presentation of malignant orbito-ocular tumors in Kano, Nigeria: A prospective multicenter study
Saudat Garba Habib1, Abdu Lawan2, Pam Victoria3
1 Department of Ophthalmology, Faculty of Clinical Sciences, College of Health Sciences, Bayero University, Kano, Nigeria
2 Department of Ophthalmology, Aminu Kano Teaching Hospital, College of Health Sciences, Bayero University Kano, Kano, Nigeria
3 Department of Ophthalmology, Ahmadu Bello University, Zaria, Nigeria
|Date of Web Publication||8-May-2019|
Dr. Saudat Garba Habib
Department of Ophthalmology, Faculty of Clinical Sciences, College of Health Sciences, Bayero University Kano, Kano
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Background: Malignant orbito-ocular tumors are major causes of morbidity and mortality in the developing countries. Their presentation, morphologic type, and management are challenging, and earlier reports were mostly retrospective surveys. Histological analysis is essential in making correct diagnosis. Here, we determined the clinical presentations and histopathologic types of orbito-ocular tumors in some tertiary hospitals in Kano, Nigeria. Materials and Methods: This was a prospective cross-sectional multicenter clinical and pathologic study conducted between June 2012 and May 2013. A structured pro forma was used to record findings, patient's biodata, clinical presentation, type of surgical intervention, and histological diagnosis. Data were analyzed with STATA version 11.0. Results: Sixty-seven eye tumors were observed among 61 patients. There were 43 males and 18 females (male-to-female ratio = 2.4:1). Patients had a mean of 13.4 ± 18.3 with a median of 4.0 (0.5–70) years with a double peak in age distribution. The most common features were visual loss (90.2%), leukocoria (59%), proptosis (55%), and fungating mass (49.2%). The symptoms were for ≥6 months in 57.4% and unilateral in 82.1%. B-scan showed retinal masses and calcifications in 13.5% and 4.5%, respectively. Confirmation by histology was achieved in 91% with the most common tumor being retinoblastoma, conjunctival squamous cell carcinoma (SCC), and rhabdomyosarcoma with frequencies of 38 (56.6%), 11 (16.4%), and 6 (9.0%), respectively. Six patients were HIV positive and all had SCC. Conclusions: Retinoblastoma was the most common malignant orbito-ocular tumor observed in this study. Patients often present late to the hospital with visual loss.
| Abstract in French|| |
Contexte: Les tumeurs malignes orbito-oculaires sont des causes majeures de morbidité et de mortalité dans les pays en développement. Leur présentation, type morphologique et la gestion sont difficiles, et les rapports précédents étaient principalement des enquêtes rétrospectives. L'analyse histologique est essentielle en faisant un diagnostic correct. Ici, nous avons déterminé les présentations cliniques et les types histopathologiques de tumeurs orbito-oculaires dans certaines hôpitaux tertiaires à Kano, au Nigeria. Matériels et méthodes: Il s'agissait d'une étude clinique et pathologique multicentrique prospective transversale. menée entre juin 2012 et mai 2013. Un formulaire pro forma a été utilisé pour enregistrer les résultats, les données biographiques du patient, la présentation clinique, type d'intervention chirurgicale et diagnostic histologique. Les données ont été analysées avec STATA version 11.0. Résultats: Soixante-sept tumeurs oculaires étaient observés chez 61 patients. Il y avait 43 hommes et 18 femmes (ratio hommes / femmes = 2,4: 1). Les patients avaient une moyenne de 13,4 ± 18,3 avec un médiane de 4,0 (0,5 à 70) années avec un double pic dans la répartition par âge. Les caractéristiques les plus courantes étaient la perte de vision (90,2%), la leucocorie (59%), proptosis (55%) et masse fongative (49,2%). Les symptômes étaient ≥ 6 mois chez 57,4% et unilatéraux chez 82,1%. B-scan a montré rétinienne masses et calcifi cations dans 13,5% et 4,5%, respectivement. La confirmation histologique a été réalisée dans 91% des cas. étant un rétinoblastome, un carcinome épidermoïde conjonctival (SCC) et un rhabdomyosarcome avec des fréquences de 38 (56,6%), 11 (16,4%), et 6 (9,0%), respectivement. Six patients étaient séropositifs et tous étaient atteints de SCC. Conclusions: Le rétinoblastome était le cancer le plus courant tumeur orbito-oculaire observée dans cette étude. Les patients se présentent souvent tardivement à l'hôpital avec une perte de vision.
Keywords: Histopathology, malignant, ocular, orbital, tumor
|How to cite this article:|
Habib SG, Lawan A, Victoria P. Clinicopathologic presentation of malignant orbito-ocular tumors in Kano, Nigeria: A prospective multicenter study. Ann Afr Med 2019;18:86-91
|How to cite this URL:|
Habib SG, Lawan A, Victoria P. Clinicopathologic presentation of malignant orbito-ocular tumors in Kano, Nigeria: A prospective multicenter study. Ann Afr Med [serial online] 2019 [cited 2019 Jul 22];18:86-91. Available from: http://www.annalsafrmed.org/text.asp?2019/18/2/86/257835
| Introduction|| |
Tumor as defined by Powell White “is a mass of cells, tissues or organs resembling those normally present but arranged atypically. It grows at the expense of the organism, without sub-serving any function.” Histopathology remains the mainstay of confirming diagnosis and determining the malignant potential of tumors.
In the underdeveloped nations, malignant tumors account for most of the orbito-ocular lesions., Studies,, from some African countries reported an average annual incidence rate of between 0.5 and 1.4 per 100,000 population.
A study in Singapore reported ocular malignancies accounting for 0.15% of all cancers with an average annual incidence rate of 1.89 per million male residents and 1.81 per million female residents. In Canada, incidence rates of malignant tumors have been reported as 6.0 and 8.1 per million among females and males, respectively.
Studies,,,, from different parts of Nigeria recorded frequencies of malignancy in ocular tumors from 56.6% to as high as 73.8%. This may be related to genetic or environmental factors.
Some studies,,,,, showed age range of 1–80 years, whereas a lower mean age was reported in a study in Lagos. Malignant childhood tumors are life threatening and could be associated with visual loss. The most common orbital malignancy in children is rhabdomyosarcoma, while the most common intraocular malignant tumor is retinoblastoma.
A study conducted in Enugu found that about 70% of pediatric patients presented at 5 years and below. Of these tumors, 38% were intraocular, 34% orbital, and 18% and 10% in the eyelid and conjunctiva, respectively.
The most common malignant orbito-ocular tumor in Asian and African adults is squamous cell carcinoma (SCC).,
| Materials and Methods|| |
The study was adhered to the Tenets of the Helsinki Declaration. Ethical approval was obtained from the Ethics Review Board of Aminu Kano Teaching Hospital. Permission was also obtained from the Medical Directors of Makkah Eye Hospital, ECWA Eye Hospital, and Murtala Muhammad Specialist Hospital. This was a cross-sectional multicenter prospective study that was carried out over a period of 12 months.
Written and informed consent was obtained from all patients or their parents, and assent was obtained from children after detailed explanation (in English and Hausa where necessary) of the nature of the study. Criteria for inclusion were patients of all age groups who had a clinical diagnosis of orbito-ocular tumor that consented to participate in the study. Exclusion criteria included proptosis from other causes, refusal of surgical intervention, and benign histology report.
Patients underwent history taking and routine ophthalmic and systemic examination. After evaluating the patient, the pro forma was filled. The presenting unaided visual acuity (VA) was assessed for distance (at a distance of 6 m) using the Snellen's chart for literate patients and illiterate “E” chart for illiterate patients. Near V/A was measured in adults with the Jaeger chart.
The Snellen's illiterate “E” or the pictorial charts were used for children >3 years at a distance of 6 m in a brightly illuminated room. For children <3 years, V/A was measured by observing fixation and following of light. In patients with fungating tumor, the eye was categorized under nil perception of light.
Anterior segment examination was undertaken with a pen torch and slit-lamp biomicroscope (where applicable). In those presenting with proptosis, extent was assessed with Hertel exophthalmometer. Pupillary reaction was tested and recorded. In cases where the pupil was not visible, it was recorded as “cannot be tested.” Posterior segment was examined by direct and indirect ophthalmoscopy with the binocular indirect ophthalmoscope.
Investigations done included skull X-ray, computed tomography (CT) scan, ocular B-scan, HIV test, full blood count, urea/electrolyte, and creatinine. Patients and guardians were counseled, and consent for surgery was obtained.
The surgical specimen was taken for histology after excision. Further management was based on the histology report warranting management by the oncologist or other specialists as the case may be.
Data obtained were entered into the Microsoft Excel and analyzed with STATA/IC version 11.0 manufactured by Quantec 2009-TEXAS USA. The association between two categorical variables (type of tumor and HIV status) was tested using Fisher's exact test. P ≤ 0.01 for Fisher's exact test was considered statistically significant.
| Results|| |
A total of 61 patients were recruited into the study; 67 eyes were examined. There were 43 males and 18 females (male-to-female ratio = 2.4:1). [Figure 1] gives the summary of age distribution. Their ages ranged from 6 months to 70 years; the age distribution is skewed. The mean age was 13.4 years with a median of 4.0 years and standard deviation (SD) of 18.3 years.
|Figure 1: Age distribution of patients with malignant orbito-ocular tumor|
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Hausa ethnic group comprised 41 patients (67.2%), while Fulani and others constituted 10 patients (16.4%) each.
Most patients presented with more than one clinical presentation [Table 1].
|Table 1: Clinical presentations in 61 patients with malignant orbito-ocular tumors|
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The tumor was unilateral in 55 (82.1%) eyes and bilateral in 12 eyes (17.9%), 10 of which had retinoblastoma [Table 2].
Of the 61 patients enrolled for the study, 47 (77.1%) were seronegative, while 8 (13.1%) declined consent to do the test. All the 6 (9.8%) seropositive patients were adult and had conjunctival SCC. Only a few patients did a CT scan due to financial constraints [Table 3].
Eleven eyes of 11 patients had SCC of the conjunctiva. Of these, 6 patients (54.5%) were HIV positive, and the relationship was statistically significant (P < 0.0001; Fisher's exact test, P < 0.0001).
All the other patients who had other malignant orbito-ocular tumors were HIV negative.
Most of the patients had modified exenteration and enucleation.
Of the 61 (91%) clinically diagnosed cases of malignant orbito-ocular tumors, there was agreement with the histopathology assessment. The most common tumors were retinoblastoma and SCC. Other tumors include fibrosarcoma, astrocytoma, and lacrimal gland tumor. Among the other tumors, fibrosarcoma and lacrimal gland tumor were clinically misdiagnosis [Table 4].
|Table 4: Comparison of clinical diagnosis with histological diagnosis in 67 eyes|
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| Discussion|| |
There were more males than females in this study. The gender disparity in presentation of patients with tumors to the hospital could be a reflection of the health-seeking behavior prevalent in the study environment. The males have liberty to seek for their health needs, whereas the females depend on their husbands for finances and also for permission to attend hospital. Similarly, some studies,, from Northern Nigeria also had a preponderance of male patients. However, a study from Southeastern Nigeria showed female preponderance. This difference within the same country but in different regions may be due to differences in sociocultural setup, such as religious beliefs, health-seeking behavior, and taboos.
Most of the patients were of Hausa ethnic group which are the major ethnic group in the environmentthe study was conducted.
More than half of the patients with malignant orbito-ocular tumor were children; hence, the data are skewed and account for the low mean age compared to the SD [Figure 1]. This observation was similarly reported in other studies,,, from various parts of Nigeria and India.
Two peaks were observed in the age distribution, one in the first decade of life and the other in patients in the third to seventh decades. The early peak is for patients with retinoblastoma and the second for patients with SCC. A study in India also reported two peaks in the age distribution of their patients with orbito-ocular tumors. Retinoblastoma is more common in children from birth to 5 years of age, with the peak age being 3 years. Bilateral retinoblastoma may even present at birth or shortly after birth. This was observed in this study with more than half of the patients with bilateral retinoblastoma presenting before 1 year of age.
The most common clinical presentations are illustrated in [Table 1]. In a hospital-based study in Thailand on orbito-ocular tumors, fungating mass and proptosis were the most common presentations. A study in Kano on childhood orbito-ocular tumors also reported fungating mass, proptosis, and leukocoria as the most common clinical presentations. In another study in Ilorin, proptosis and chemosis occurred in 84.6% and leukocoria in 61.50%. These studies, indicate the pattern of presentation of the disease in that environment.
An earlier study in Kano reported that the duration of symptoms before seeking medical care was 6 months or more. Late presentation to the hospital could be due to the lack of awareness, misconception of the disease, and poverty. Furthermore, the sociocultural belief and probably poor accessibility to tertiary eye institution could have contributed to the delay in presentation.[Figure 2]
|Figure 2: More than 50% of the patients had a duration of ≥ 6 months before presentation to the hospital|
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Orbito-ocular tumor involved the right eye more than the left with a small number having bilateral manifestation similar to some studies, in Nigeria and Nepal. More than half of the tumors were retinoblastoma and may be sporadic in nature. The bilateral cases of this condition in the study are most likely of genetic origin. Further confirmation of this could be carried out by genetic studies.
Seventy-seven (77%) of the patients were HIV seronegative and 9.8% were seropositive, while 13.1% declined consent to do the test because they are apprehensive of knowing their HIV status.
Some studies, found HIV seropositivity in patients with SCC to be 75%. However, in this study, HIV positivity among patients with conjunctival SCC was 54.6%, and the Fischer's test demonstrates a statistically significant association between HIV positivity and SCC. The difference in incidence may be due to the sociocultural practices, exposure to the risk factors, and also the small sample size.
Among the patients who had ocular B-scan [Table 5], some had retrolental mass, a few had calcification, while other patients had normal findings. Skull X-ray showed that soft-tissue shadow in some patients but no orbital calcification, or bone destruction were seen. Furthermore, a study showed retinal masses and calcification in 88.9% of the patients who were scanned. Hence, a high-resolution B-scan can be helpful in early detection of retinoblastoma, particularly those in the anterior segment. Ocular B-scan appears to be more useful than skull X-ray in detecting intraocular calcification.
|Table 5: Types of surgical procedure performed in 67 eyes with malignant orbito-ocular tumors|
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Modified exenteration was the most common surgery performed for advanced tumors comparable with other studies from Northern Nigeria where it was performed in 74% and 73.4% of patients, respectively.,
Retinoblastoma was the most common orbito-ocular malignancy similar to findings reported in other studies,,, from the southwest, northeast, and northwest zones of the country. However, a study from the southeast zone had an incidence (38.1%) slightly lower than that from the northwest and southwest zones. This difference in incidence in the same country may be due to genetic and environmental factors and probably culture. Studies, from Singapore and Nepal also reported a high incidence of retinoblastoma in their series. The second most common orbito-ocular tumor seen in this study was conjunctival SCC. This finding is similarly reported in other studies,, with incidence rates of 11.6%–18.9%, respectively. In Singapore, SCC accounted for 11.2% of malignant orbito-ocular tumors. Increased frequency of this tumor may be due to the HIV pandemic.
The most common orbital lymphoma was Burkitt's lymphoma (BL) similar to what was observed in Northeastern Nigeria and Congo. The reported incidence of BL was 2.6% and 3% of the patients in those series. This study reported frequency much lower than 9.6% in Zaria. The difference between the incidence rates of BL in comparable environment may be due to difference in the study design and time period covered. In studies, from Southwestern and Southeastern Nigeria, BL constituted 21.4% and 9.3% of malignant orbito-ocular tumors, although the identified predisposing factors such as malaria, heavy rainfall, and malnutrition are similar for both the regions.
In most cases, clinical diagnosis accurately correlated with the histological diagnosis. Orbito-ocular tumors can be diagnosed clinically with a high degree of accuracy as shown in this study. This finding may justify initial chemotherapy/chemoreduction in patients with advanced retinoblastoma before surgery is performed where indicated. An earlier study reported histological confirmation in 98% of patients with retinoblastoma.
Histopathology still plays a vital role in confirmation of orbito-ocular tumors. However, with improved diagnostic skill and high index of suspicion, chemoreduction and laser treatment of some ocular and orbital tumors could be given without waiting for histopathological confirmation, especially for patients under the care of an ocular oncology team.
| Conclusions|| |
The most common presenting symptom was visual loss often with late presentation. Retinoblastoma and conjunctival SCC were the most common malignant orbito-ocular tumors.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Yanoff M, Fine B. Ocular Pathology. 4th
ed. Missouri, USA: Mosby, Elsevier; 2008. p. 32.
Akpe BA, Omoti AE, Iyasele ET. Histopathology of ocular tumor specimens in Benin city, Nigeria. J Ophthalmic Vis Res 2009;4:232-7.
Templeton AC. Tumors of the eye and adnexa in Africans of Uganda. Cancer 1967;20:1689-98.
Bekibele CO, Oluwasola AO. A clinicopathological study of orbito-ocular diseases in Ibadan between 1991-1999. Afr J Med Med Sci 2003;32:197-202.
Bah E, Parkin DM, Hall AJ, Jack AD, Whittle H. Cancer in the Gambia: 1988-97. Br J Cancer 2001;84:1207-14.
Koulibaly M, Kabba IS, Cissé A, Diallo SB, Diallo MB, Keita N, et al.
Cancer incidence in Conakry, Guinea:First results from the cancer registry 1992-1995. Int J Cancer 1997;70:39-45.
Chokunonga E, Levy LM, Bassett MT, Mauchaza BG, Thomas DB, Parkin DM, et al.
Cancer incidence in the African population of Harare, Zimbabwe: Second results from the cancer registry 1993-1995. Int J Cancer 2000;85:54-9.
Lee SB, Au Eong KG, Saw SM, Chan TK, Lee HP. Eye cancer incidence in Singapore. Br J Ophthalmol 2000;84:767-70.
Ayiomamitis A. Epidemiologic features of cancer of the eye, orbit and related adnexa in Canada. Can J Ophthalmol 1989;24:269-74.
Olurin O, Williams AO. Orbito-ocular tumors in Nigeria. Cancer 1972;30:580-7.
Mohammed A, Ahmed SA, Ahmed NE, Maisamari JS. Orbito-ocular tumors in Zaria. A ten year review. Ann Afr Med 2006;5:129-31.
Abiose A, Adido J, Agarwal SC. Childhood malignancies of the eye and orbit in Northern Nigeria. Cancer 1985;55:2889-93.
Ochicha O, Ekanem IO. Tumors of the eye and adnexa in the South Eastern Nigeria. A histopathological study. Sahel Med J 1999;2:21-4. [Full text]
Ademola-Popoola DS, Owoye JF, Afolayan EA, Adepoju GF. Spectrum of Orbito-Ocular Tumors in Ilorin, Nigeria. Washington DC, USA: UICC World Cancer Congress; 2006.
Anunobi CC, Akinsola FB, Abdulkareem FB, Aribaba OT, Nnoli MA, Banjo AA, et al.
Orbito-ocular lesions in Lagos. Niger Postgrad Med J 2008;15:146-51.
Castillo BV Jr., Kaufman L. Pediatric tumors of the eye and orbit. Pediatr Clin North Am 2003;50:149-72.
Onwasigwe EN. Orbito ocular tumors in Nigerian children. J Coll Med 2002;7:101-3.
Kumar R, Adhikari RK, Sharma MK, Pokharel DR, Gautam N. Pattern of ocular malignant tumors in Bhairahwa, Nepal. Int J Ophthalmol Vis Sci 2009;7:1528-8269.
Umar AB, Ochicha O, Iliyasu YA. Pathologic review of ophthalmic tumor in Kano, Northern Nigeria. Niger J Basic Clin Sci 2012;9:23-6. [Full text]
Askira BH, Nggada HA. Orbito-ocular malignancy in Maiduguri North Eastern Nigeria. A histopathology review. Int J Ophthalmol Vis Sci 2006;5:1,1-4.
Mahmoud AO, Buari MB, Adekoya BS. Pattern of orbito ocular growths in Ilorin, Nigeria. Trop J Health Sci 2007;14:23-7.
Chinda D, Samaila MO, Abah ER, Garba F, Rafindadi AL, Adamu A. A clinico-pathological study of orbito-ocular tumors at Ahmadu Bello university teaching hospital Shika-Zaria, Nigeria. A 5-year review. Clin Cancer Invest J 2012;1:145-7.
Chuka-Okosa CM, Uche NJ, Kizor-Akaraiwe NN. Orbito-ocular neoplasms in Enugu, South-Eastern, Nigeria. West Afr J Med 2008;27:144-7.
Sunderraj P. Malignant tumours of the eye and adnexa. Indian J Ophthalmol 1991;39:6-8.
] [Full text]
Jack JK. Clinical Ophthalmology. A Systemic Approach. 6th
ed. Oxford: Butterworth Heinmann; 2007. p. 109-549.
Fonthip NP, Wasse T, Keerati P. Malignant tumors of the eye and ocular adnexa in Thailand: A six year review at King Chulalong memorial hospital. Asian Biomed 2009;3:551-5.
Abdu L, Mohammed AZ. Clinico-pathological pattern of childhood orbito-ocular tumors. A five year review. Nigr J Basic Clin Sci 2006;3:17-21.
Owoeye JF, Afolayan EA, Ademola-Popoola DS. Retinoblastoma-a clinico-pathological study in Ilorin, Nigeria. Afr J Health Sci 2006;13:117-23.
Ateenyi-Agaba C. Conjunctival squamous-cell carcinoma associated with HIV infection in Kampala, Uganda. Lancet 1995;345:695-6.
Osahon AI, Ukponmwan CU, Uhunmwangho OM. Prevalence of HIV seropositivity among patients with squamous cell carcinoma of the conjunctiva. Asian Pac J Trop Biomed 2011;1:150-3.
Finger PT, Meskin SW, Wisnicki HJ, Albekioni Z, Schneider S. High-frequency ultrasound of anterior segment retinoblastoma. Am J Ophthalmol 2004;137:944-6.
Thakur SK, Sah SP, Lakhey M, Badhu BP. Primary malignant tumours of eye and adnexa in Eastern Nepal. Clin Exp Ophthalmol 2003;31:415-7.
Poso MY, Mwanza JC, Kayembe DL. Malignant tumors of the eye and adnexa in Congo-Kinshasa. J Fr Ophtalmol 2000;23:327-32.
[Figure 1], [Figure 2]
[Table 1], [Table 2], [Table 3], [Table 4], [Table 5]