Annals of African Medicine
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ORIGINAL ARTICLE
Year : 2010  |  Volume : 9  |  Issue : 3  |  Page : 141-146

Correlation of oxidative stress and inflammatory markers with the severity of sickle cell nephropathy


1 Department of Chemical Pathology, Aminu Kano Teaching Hospital, Kano; Department of Medical Laboratory Science, School of Basic Medical Sciences, University of Benin, Benin city, Nigeria
2 Department of Biochemistry, University of Benin, Benin city, Nigeria
3 Department of Chemical Pathology, Aminu Kano Teaching Hospital, Kano; Department of Chemical Pathology, University of Maiduguri, Maiduguri, Nigeria

Correspondence Address:
M A Emokpae
Department of Medical Laboratory Science, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin city
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1596-3519.68363

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Background: Reactive oxygen species have been shown to mediate inflammatory process and may be involved in lipid peroxidation. Methods: This study evaluates superoxide dismutase, glutathione peroxidase, catalase, malondialdehyde, C- reactive protein and fibrinogen in the serum of patients with sickle cell disease and their correlation with renal insufficiency. Superoxide dismutase, glutathione peroxides and C - reactive protein were assayed using sandwich ELISA technique while malondialdehyde and fibrinogen were determined using thiobarbituric reactive substance and turbidometric technique, respectively. Results: The study group consisted of 40 patients with sickle cell disease along with macroalbuminuria, 16 with chronic kidney disease and 144 sickle cell disease controls. Superoxide dismutase, glutathione peroxidase and catalase were decreased while malondialdehyde, C-reactive protein and fibrinogen were increased in patients with sickle cell disease along with renal insufficiency. These parameters correlated with the severity of renal disease. Conclusion: Oxidative stress and inflammatory parameters correlate with sickle cell disease nephropathy.


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