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ORIGINAL ARTICLE
Year : 2009  |  Volume : 8  |  Issue : 1  |  Page : 19-24 Table of Contents     

Endophthalmitis: Magnitude, treatment and visual outcome in northwest frontier province of Pakistan


1 Department of Ophthalmology, Jos University Teaching Hospital, Jos, Nigeria
2 Khyber Institute of Ophthalmic Medical Science, Hayatabad Medical Complex, Peshawar, Pakistan

Date of Acceptance07-Sep-2008
Date of Web Publication19-Sep-2009

Correspondence Address:
P D Wade
Department of Ophthalmology, Jos University Teaching Hospital, Jos
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1596-3519.55759

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   Abstract 

Background :Many cases of post-operative and posttraumatic endophthalmitis are being managed at the Khyber Institute of Ophthalmic Medical Sciences, Peshawar in Pakistan but no study has been done to ascertain the magnitude of the disease and to also evaluate the visual outcome after management.
Methods : The case notes of 39 patients diagnosed with posttraumatic and postoperative endophthalmitis between May 2006 and April 2007 were analyzed and clinical characteristics obtained were documented and tabulated.
Results : During the study period, 2474 patients were admitted in both the male and female wards. Of these, 39 (1.6%) had endophthalmitis due to surgical and traumatic complications. In all, 6 (12.4%) patients had evisceration, while 21 (53.8%) patients who had topical antibiotics consisting of ofloxacin, 0.1% corticosteroids, fortified cetazoline and 1% atropine along with intravitreal antibiotics, a combination of 0.1mg vancomycin and 0.4mg amikacin, were discharged home with a visual acuity of counting fingers to light perception.
Conclusion : Endophthalmitis is a serious ocular complication of open globe injury and intraocular surgery. The frequency in this center has been noted to be very high as compared to other places. Its management is very challenging and often leads to devastating structural and functional damage to the eye; causing severe frustration to both the patient and the attending physician. Efforts must be made to prevent the condition.

   Abstract in French 

Résumé
Fond
Beaucoup de cas de postopératoire et de poteau-traumatique endophthalmite sont contrôlés à l'institut de Khyber des sciences médicales ophtalmiques, Peshawar au Pakistan mais non étude a été fait pour s'assurer l'importance de la maladie et pour évaluer également les résultats visuels après gestion.
Méthodes Les notes de cas de 39 patients diagnostiqués avec l'endophthalmite poteau-traumatique et postopératoire entre mai 2006 et l'avril 2007 ont été analysées et des caractéristiques cliniques obtenues ont été documentées et tabulées
Résultats Pendant la période d'étude, 2.474 patients ont été admis dans les salles masculines et femelles. De ces derniers, 39 (1.6%) ont eu l'endophthalmite due aux complications chirurgicales et traumatiques. En tout, 6 (12.4%) patients ont eu l'éviscération, tandis que 21 (53.8%) patients qui ont eu les antibiotiques topiques se composer de l'ofloxacin, 0.1% corticostéroïde, cetazoline et atropine enrichie de 1% avec les antibiotiques intravitreal, une combinaison du vancomycin 0.1mg et de l'amikacine 0.4mg, étaient maison déchargée avec une acuité visuelle de compter des doigts pour allumer la perception.
Conclusion L'endophthalmite est une complication oculaire sérieuse des dommages ouverts de globe et de chirurgie intraocular. La fréquence à ce centre a été notée pour être très haute par rapport à d'autres endroits. Sa gestion est très provocante et mène souvent à dévaster des dommages structuraux et fonctionnels à l'oeil ; entraînant l'anéantissement grave au patient et au médecin étant présent. Des efforts doivent être faits pour empêcher la condition.

Keywords: Endophthalmitis, magnitude, visual outcome


How to cite this article:
Wade P D, Khan S S, Khan M D. Endophthalmitis: Magnitude, treatment and visual outcome in northwest frontier province of Pakistan. Ann Afr Med 2009;8:19-24

How to cite this URL:
Wade P D, Khan S S, Khan M D. Endophthalmitis: Magnitude, treatment and visual outcome in northwest frontier province of Pakistan. Ann Afr Med [serial online] 2009 [cited 2018 Jan 16];8:19-24. Available from: http://www.annalsafrmed.org/text.asp?2009/8/1/19/55759

Endophthalmitis describes the inflammatory response of the eye to intraocular infection and sometimes toxins from the organisms, which constitutes a true emergency. It is the most dreaded and devastating complication of intraocular surgery with a potential to lead to permanent and profound loss of vision.[1] Postoperative endophthalmitis is the most common form, comprising up to 70% of infective endophthalmitis. Posttraumatic endophthalmitis follows open-globe injuries and accounts for one-fifth of all cases.[2] The incidence of endophthalmitis from postoperative ocular complications is 0.07%-4%.[3],[4],[5],[6]

Intraoperative posterior capsule rupture is associated with an 8 to11 fold increased risk of acute endophthalmitis,[3] while contamination of topical medications, patient's own flora, virulence of inoculated pathogens and immune status are recognized risk factors for endophthalmitis.[7],[8],[9]

The symptoms of endophthalmitis are blurred vision, redness and pain, while the signs include conjunctival hyperaemia, anterior chamber and vitreous cells, hypopyon, lid edema, chemosis, corneal edema, reduced red reflex and afferent pupillary defect.[10] In endophthalmitis, the most common microorganisms cultured from the ocular surface and anterior chamber are staphylococcal aureus and staphylococcal epidermidis.[8] Posttraumatic endophthalmitis associated with open globe injury represents a distinct kind of intraocular infection,[10] and the risk factors include the presence of an intraocular foreign body, injury inflicted by organic material, delay in surgery and the type of wound involved.[11] The main treatment is intravitreal antibiotics used in conjunction with subconjunctival, topical and intravenous antibiotics and corticosteroids.[12] The Endophthalmitis - vitrectomy study concluded that routine immediate vitrectomy is not necessary in patients with better than light perception vision at presentation but of substantial benefit for those who have light perception only vision.[13] Delay in primary wound closure or inadequate treatment worsens the visual prognosis,[10] while removal of the intraocular foreign body within 24 hours of injury has been found to markedly reduce the risk of infectious endophthalmitis.[14] We undertook this study to:

  1. Determine the frequency of admitted cases of endophthalmitis in our center
  2. Determine the visual outcome following treatment
  3. Compare our results with those obtained in other parts of the world
  4. Prospectively assess the etiology, and effect of management of endophthalmitis on patients, quality of life.

   Patients and Methods Top


Hayatabad medical complex, Peshawar is one of the 3 major tertiary hospitals in the North West Frontier Province of Pakistan. The Khyber Institute of Ophthalmic medical Sciences (KIOMS) serves as a referral center to the peripheral clinics, the district hospitals and parts of Afghanistan. From May 2006 to April 2007, 2474 patients were admitted in both the male and female eye wards. The case notes of thirtynine patients diagnosed with endophthalmitis from postoperative and posttraumatic complications were retrieved. Information on age, gender, history of presenting complaints such as pains, poor vision and duration were obtained. Other information includes systemic illness, general and ocular examinations. The investigations, treatment and visual outcome on discharge were also noted. These were filled in a prepared proforma and analyzed. The results are presented in tables.


   Results Top


During the period of study, 2474 patients were admitted. 1363 patients had cataract extractions, 154 had glaucoma surgery and 36 had vitreoretinal surgery. One hundred and eight patients were managed for open and closed globe injuries.

Thirty-nine (1.6%) were treated for endophthalmitis secondary to postoperative and posttraumatic complications. There were 31 (79.5%) males and 8 (20.5%) were females giving a male to female ratio of about 4:1. Children aged 1 to 10 years were mostly affected and this is closely followed by those between 11 to 20 years. Posttraumatic endophthalmitis accounted for 27(69.2%) [Table 1], while postoperative endophthalmitis following cataract surgery occurred in 12 (23.1%) [Table 2].

Most of the specimens (vitreous tap) sent yielded no growth while staphylococcal aureus was isolated in 2 (5.1%), others were one case (2.6%) of E coli, pseudomonas and septate hyphae. All the patients had antibiotic treatment with ofloxacin, 0.1% corticosteroids, fortified cetazoline and 1% antibiotics given topically, while 0.1mg vancomycin and 0.4mg amikacin were administered intravitreally. Six (15.4%) patients had evisceration, while 2 (5.1%) had intraocular foreign bodies removed. The visual outcome on discharge was not too encouraging as 21 (53.8%) patients were discharged home with a visual acuity of counting finger to perception of light. Their visual acuities were either better or same on admission as shown on both tables. Twelve (30.8%) patients had no perception of light.


   Discussion Top


Endophthalmitis is a tragic occurrence, be it after an intraocular surgery or following trauma, and with this event the hopes of the patient is vanished, while the confidence of the ophthalmologist is shattered.[14] Efforts must be made as much as possible to prevent its occurrence.

Endophthalmitis accounted for 1.6% of all cases seen within the study period with posttraumatic endophthalmitis being higher, seen in 27(1.6%) patients than postoperative complications occurring in 12(0.5%) cases. These values are higher than most values seen in the literature. Mollar et al[5] had an incidence of 0.099% endophthalmitis following cataract surgery in Birmingham, so also Lautha et al6 in South India, a similar Asian population recorded an incidence of 0.05% cases secondary to cataract surgery. Other workers[3],[15],[16] also recorded lower values than seen in this study. Successful cataract surgery restores failing eyesight, and is also responsible for permanent and significant loss of vision resulting from severe endophthalmitis in upto 0.1% patients.[17] There is a need therefore, in our prospective study to identify the reason for the high values obtained in this center.

Posttraumatic endophthalmitis is a complication of penetrating eye injuries that results in blindness in potentially salvageable eyes.[18] Of the 154 patients treated for trauma during this period 27(17.5%) had endophthalmitis. Other similar studies[13],[19] had lower figures of 6.8% and 5.0% respectively, while the study in Vietnam[10] recorded a much higher value of 11.8% but still lower than that obtained in our study. The risk factors identified were dirty wounds, retained intraocular foreign bodies; lens capsule breach, delayed wound repair and rural address.[19] Most of the cases of posttraumatic endophthalmitis were either referred from district or peripheral hospitals or the patients have attempted self medication before presentation. Only one patient reported within 24 hours of injury. Nine (33.3%) patients with posttraumatic endophthalmitis had thorn or stick injuries. This is due to the fact that this is a farming community and the injuries occurred on the farms. Children pick dirty needles thrown around to play with and this accounts for the 4(14.8%) cases seen. These instruments carry along organisms as they penetrate the eye at the time of injury causing devastating effect. Narang et al[20] in India have attributed the high risk of posttraumatic endophthalmitis to bow and arrow, and household injuries.

Postoperative endophthalmitis remains a serious clinical problem in ophthalmology, and prognosis is largely determined by the virulence of the offending organisms.[21] Only 1(8.3%) vitreous aspirate in patients with postoperative endophthalmitis yielded pseudomonas specie . Others in South India[22] cultured norcadia species in 60% of cases and coagulase negative and E. coli were also isolated. Ng et al23 had 84 % gram positive cocci and streptococci , while enterococci and staphylococci were isolated in 19.1% and 18.3% respectively. Other studies[15],[16] identified coagulase negative cocci, S. epidermidis and S aureus in their various studies. Postoperative endophthalmitis caused by organisms other than coagulase-negative staphylococcus or P. aureus carries a poor visual prognosis.[24]

The low rate of culture positivity in this study could be due to poor sampling technique, the use of antibiotics postoperatively or simply sterile endophthalmitis. Endophthalmitis following openglobe injuries is caused by a specific range of microorganisms of which bacillus specie and coagulase negative staphylococcus are the most frequent.[25] The vitreous aspirate of only 1 (3.7%) patient yielded fungal septate hyphae, while E coli and Staphylococcus aureus were cultured in the specimen of one (3.7%) patient, though the B-scan showed infective process in 7 (25.9%) patients' vitreous cavities. Davey et al[26] have reported far less cases of fungal infection, but found bacillus species as increasingly major causes of posttraumatic ocular diseases. Other studies[18],[27] also found the bacillus species to be the most important cause of posttraumatic endophthalmitis.

Current recommended approach to suspected posttraumatic infection involves early diagnostic vitrectomy and intraocular culture, use of intravitreal antibiotics and combination of treatment with systemic and periocular antibiotics.[26] In this study patients were treated with intravitreal antibiotics using a combination of 0.1mg vancomycin and 0.4mg amikacin. Topical eye drops included ofloxacin, 0.1% corticosteroids, fortified cefazoline, and 1% atropine. Four (10.3%) patients had pars plana vitrectomy as an adjunct to treatment. No oral, intravenous or subconjunctival injections were given. Ng et al[23] had poorer visual outcome without antibiotics than with oral antibiotics, while Cuila et al[15] found that use of subconjunctival antibiotic in routine intraocular surgery received a clinical recommendation of "C", indicating that it may be relevant but cannot be definitely related to clinical outcome.

Only the visual outcome on discharge could be obtained from the files as patients follow up were not recorded. One (8.3%) patient with postoperative endophthalmitis had a pretreatment visual acuity of 6/18 and was subsequently discharged on same visual acuity. Nine (75.0%) patients had pretreatment visual acuity of counting fingers to light perception, out of which 2(16.7%) patients had non-perception of light as 1(8.3%) one was eventually eviscerated.

The visual outcome in those due to posttraumatic endophthalmitis were also similar with 2(7.4%) patients presenting with pretreatment visual acuity of 6/12 and 6/ 18 but were discharged with visual acuities of light perception and hand movement respectively. Seventeen (63.0%) cases had visual acuity of counting fingers to light perception on admission but only 12(44.4%) patients were discharged with same visual acuity. Four (14.8%) eyes were eviscerated. Visual outcome in posttraumatic endophthalmitis is generally poor as recorded by other workers,[21],[25] but Brimton et al[28] had 26% of patients with final visual acuity of 6/9 (20/30) and 42.1% had 6/60(20/200) or better.

Endophthalmitis, be it due to postoperative or posttraumatic complications have a very devastating effect. The frequency of endophthalmitis in this center has been noted to be very high as compared to other studies. Effort must be made to identify the cause in order to find an optimal management option.[29]

Recommendations

  1. There is need to have a continuous medical education program for general practitioners and primary eye care providers on the devastating effect of endophthalmitis.
  2. Health education to all patients at the outpatient clinic on the dangers of selfmedication and the need to seek immediate attention in cases of eye injuries.
  3. Parents should be involved in the management of their children's condition
  4. The eye wards, operating theaters, instruments and consumables must be kept clean and sterile.
  5. More research is indicated to find out the causes of the high prevalence and incidence, poor yield of microorganisms on microscopy and culture and the poorer outcome of treatment in the department.


 
   References Top

1.Olson RJ. Challenges in ocular infectious diseases and the evolution of anti-infective therapy. Surv Ophthalmol. 2004; 49:S53-S54.   Back to cited text no. 1      
2.Das T, Derek KY, Savitri S, et al. Relationship between clinical presentation and visual outcome in postoperative and posttraumatic endophthalmitis in South Central India. Indian J Ophthalmol 2000; 48:123-128.   Back to cited text no. 2      
3.Aarberg TM Jr, Flynn HW Jr, Schiffman J, Newton J. Nosocomial acute-onset postoperative endophthalmitis survey. A 10-year review of incidence and outcomes. Ophthalmology. 1998; 105:1004-1010.   Back to cited text no. 3      
4.Wong TY, Chee SP. The Epidemiology of acute endophthalmitis after cataract surgery in an Asian population. Ophthalmology. 2004; 11:699-705.   Back to cited text no. 4      
5.Mollan SP, Gao A, Lockwood A. Endophthalmitis: incidence and microbial isolates in a United Kingdom region from 1996 through 2004. J Cataract Refract Surg. J Cataract Refract Surg. 2007; 33:265-268.   Back to cited text no. 5      
6.Lalitha P, Rajagopalan J, Prakash K, Ramasamy K, Prajna NV, Srinivasan M. Postcataract endophthalmitis in South India: incidence and outcome. Ophthalmology. 2005; 112:1884-1889.   Back to cited text no. 6      
7.Mistlberger A, Ruchofer J, Rathel E, et al. Anterior chamber contamination during cataract surgery with intraocular lens implantation. J Cataract Refract Surg. 1997; 23:1064-1069.   Back to cited text no. 7      
8.Bausz M, Fodor E, Resch MD, Kristof K. Bacterial contamination in the anterior chamber after povidone iodine application and the effect of lens implantation device. J Cataract Refract Surg. J Cataract Refract Surg. 2006; 32:1691-1695.   Back to cited text no. 8      
9.Samad A, Solomon LD, Miller MA, Mendelson J. Anterior chamber contamination after uncomplicated phaecoemulsification and intraocular lens implantation. Am J Ophthalmol. Am J Ophthalmol. 1995; 120:143-150.   Back to cited text no. 9      
10.Tran TP, Le TM, Bui HT, Nguyen TM, Kuchle M, Nguyen NX. Posttraumatic endophthalmitis after penetrating injury in Vietnam: risk factors, microbial aspect and visual outcome. Klin Monatsbl Augenheilkd. 2003; 220:481-485.   Back to cited text no. 10      
11.Duch-Samper AM, Chaques-Alepuz V, Menezo JL, Hurtado-Sarrio M. Endophthalmitis following openglobe injuries. Curr Opin Ophthalmol. 1998; 9:59-65.   Back to cited text no. 11      
12.Hawkins AS, Deutsch TA. Infectious endophthalmitis. Curr Infect Dis Rep. 1999; 1:172-177.   Back to cited text no. 12      
13.Endophthalmitis - vitrectomy Study Group. Arch Ophthalmol. 1995; (12): 1479- 96.http://www.ncbi.nlm.hih.gov/pubmed/748761. (Accessed 22/07/08)   Back to cited text no. 13      
14.Thompson JT, Parver LM, Enger CL, Mieler WF, Ligett PE. Infectious endophthalmitis after penetrating injuries with retained intraocular foreign body. National Eye Trauma System. National Eye Trauma. Ophthalmology. 1993; 100:1468-1474.   Back to cited text no. 14      
15.Ciulla TA. StarrMb, Masket S. Bacterial endophthalmitis prophphylaxis for cataract survey. An Evidence-based update. Ophthalmology. 2002; 109:13-24.   Back to cited text no. 15      
16.Taban M, Behrens A, Newcomb RL, et al. Acute Endophthalmitis following cataract surgery. A systematic review of literature. Arch Ophthalmol. 2005; 123:613-620.   Back to cited text no. 16      
17.Seal DV, Barry P, Gettinby G, et al. ESCRS study of prophylaxis of postoperative endophthalmitis after cataract surgery. Case for a European multicenter study. J Cataract Refract Surg. 2006; 32:396-406.   Back to cited text no. 17      
18.Alfaro DV, Roth D, Ligett PE. Posttraumatic endophthalmitis, causative organisms, treatment and prevention. Retina. 1994; 14:206-211.   Back to cited text no. 18      
19.Soheilian M, Rafati N. Post-traumatic endophthalmitis. Ophthalmology. 2005; 112:1845-1846.   Back to cited text no. 19      
20.Narang S, Gupta V, Simakundhi P, Gupta A. raj S, Dogra MR. Paediatric open globe injuries. Visual outcome and risk factors for endophthalmitis. Indian J Ophthalmol 2004; 52:29-34.   Back to cited text no. 20      
21.Hanscom TA. Postoperative endophthalmitis. Clin Infect Dis. 2004; 38:542-546.   Back to cited text no. 21      
22.Lalitha P, Rajagopalan J, Prakash K, Ramasamy K, Prajna NV, Srinivasan M. Postcataract endophthalmitis in South India. Ophthalmology. 2005; 112:1885-1889.   Back to cited text no. 22      
23.Ng JQ, Morlet N, Pearman JW, Semmens JB. Management and outcomes of postoperative endophthalmitis since the endophthalmitis vitrectomy study. The endophthalmitis population study of Western Australia (EPSWA)'s fifth Report. Ophthalmology. 2005; 112:1199.   Back to cited text no. 23      
24.Somani S, Grinbaum A, Slomovic AR. Postoperative endophthalmitis: incidence predisposing surgery, clinical course and outcome. Can J Ophthalmol. 1997; 32:303-310.  Back to cited text no. 24      
25.Sabaci G, Bayer A. muthi FM, Karaguul S, Yildirim E. Endophthalmitis after deadly-weapon-related openglobe injuries. Risk factors, value of prophylactic antibiotics and visual outcomes. Am J Ophthalmol. Am J Ophthalmol. 2002; 133:62-69.   Back to cited text no. 25      
26.Davey RT, Tauber WB. Posttraumatic endophthalmitis: The emerging role of Bacillus cereus infection. Rev Infect Dis. 1987; 9:110-123.   Back to cited text no. 26      
27.Kunimoto DY, Daa T, Sharma S, et al. Micrbiologic spectrum and susceptibility of isolates: Part II. Post traumatic endophthalmitis. Endophthalomitis Research group. Am J Ophthalmol. Am J Ophthalmol. 1999; 128:242-244.   Back to cited text no. 27      
28.Brinton GS, Topping TM, Hynduk RA, Aerberg TM, Reeser FH, Abrams GW. Posttraumatic endophthalmitis. Arch Ophthalmol. 1984; 102:547- 550.   Back to cited text no. 28      
29.Das T. National endophthalmitis survey. Indian J Ophthalmol 2003; 51:117-118.  Back to cited text no. 29  [PUBMED]  Medknow Journal  



 
 
    Tables

  [Table 1], [Table 2]


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